健康日本人群中大麦摄入量与肠道微生物群特征的关系：一项横断面研究。
Relationships between barley consumption and gut microbiome characteristics in a healthy Japanese population: a cross-sectional study.
作者信息
Matsuoka Tsubasa, Hosomi Koji, Park Jonguk, Goto Yuka, Nishimura Mao, Maruyama Satoko, Murakami Haruka, Konishi Kana, Miyachi Motohiko, Kawashima Hitoshi, Mizuguchi Kenji, Kobayashi Toshiki, Yokomichi Hiroshi, Kunisawa Jun, Yamagata Zentaro
机构信息
Research and Development Department, Hakubaku Co., Ltd., 4629, Nishihanawa, Chuo, Yamanashi, 409-3843, Japan.
Department of Health Sciences, School of Medicine, University of Yamanashi, 1110, Shimokato, Chuo, Yamanashi, 409-3898, Japan.
出版信息
BMC Nutr. 2022 Mar 14;8(1):23. doi: 10.1186/s40795-022-00500-3.
BACKGROUND
Barley contains abundant soluble beta-glucan fibers, which have established health benefits. In addition, the health benefits conferred by the gut bacteria have attracted considerable interest. However, few studies have focused on the barley consumption and gut bacteria of the Japanese population. In this study, we aimed to identify the relationship between the barley consumption and gut bacteria composition of the Japanese population.
METHODS
In total, 236 participants were recruited in Japan, and 94 participants with no complications of diabetes, hypertension, or dyslipidemia were selected for the study. We analyzed fecal samples from the participants, their medical check-up results, and responses to questionnaires about dietary habits. The participants were grouped according to their median barley consumption. Then, we assessed the relative abundance of 50 genera. Characteristic bacteria were evaluated for their relationship with barley consumption by multiple regression analysis, adjusted for disease and dietary habits, in all participants. We also analyzed the networks and clustering of the 20 selected genera.
RESULTS
According to the comparison between barley groups, Bifidobacterium, Butyricicoccus, Collinsella, Ruminococcus 2, and Dialister were characteristic candidate bacterias of the group that consumed large amounts of barley (P < 0.05). The relationship between barley consumption and Bifidobacterium remained after adjusting for disease and dietary habits, and that of Butyricicoccus remained after adjusting for disease. Furthermore, network and cluster analyses revealed that barley consumption was directly correlated with Bifidobacterium and Butyricicoccus.
CONCLUSIONS
Barley consumption generates changes in the intestinal bacteria of the Japanese population. We found that Bifidobacterium and Butyricicoccus abundance was positively associated with barley consumption.
背景
大麦含有丰富的可溶性β-葡聚糖纤维，已证实其对健康有益。此外，肠道细菌带来的健康益处也引起了广泛关注。然而，很少有研究关注日本人群的大麦摄入量与肠道细菌的关系。在本研究中，我们旨在确定日本人群的大麦摄入量与肠道细菌组成之间的关系。
方法
在日本共招募了236名参与者，选择了94名无糖尿病、高血压或血脂异常并发症的参与者进行研究。我们分析了参与者的粪便样本、体检结果以及关于饮食习惯的问卷调查回复。根据参与者大麦摄入量的中位数进行分组。然后，我们评估了50个菌属的相对丰度。通过多因素回归分析评估特征性细菌与大麦摄入量之间的关系，并对所有参与者的疾病和饮食习惯进行了校正。我们还分析了20个选定菌属的网络和聚类情况。
结果
根据大麦摄入量分组的比较，双歧杆菌属、丁酸球菌属、柯林斯菌属、瘤胃球菌2属和戴阿利斯特菌属是大量摄入大麦组的特征性候选细菌（P < 0.05）。校正疾病和饮食习惯后，大麦摄入量与双歧杆菌属之间的关系仍然存在，校正疾病后，丁酸球菌属与大麦摄入量的关系仍然存在。此外，网络和聚类分析表明，大麦摄入量与双歧杆菌属和丁酸球菌属直接相关。
结论
摄入大麦会使日本人群的肠道细菌发生变化。我们发现双歧杆菌属和丁酸球菌属的丰度与大麦摄入量呈正相关。
Zotero 插件