New Industry Creation Hatchery Center (NICHe), Tohoku University, Sendai 980-8579, Japan.
Molecules. 2022 Aug 25;27(17):5451. doi: 10.3390/molecules27175451.
Iron is the most abundant mineral in the human body and plays essential roles in sustaining life, such as the transport of oxygen to systemic organs. The Fenton reaction is the reaction between iron and hydrogen peroxide, generating hydroxyl radical, which is highly reactive and highly toxic to living cells. "Ferroptosis", a programmed cell death in which the Fenton reaction is closely involved, has recently received much attention. Furthermore, various applications of the Fenton reaction have been reported in the medical and nutritional fields, such as cancer treatment or sterilization. Here, this review summarizes the recent growing interest in the usefulness of iron and its biological relevance through basic and practical information of the Fenton reaction and recent reports.
铁是人体中含量最丰富的矿物质，对维持生命起着至关重要的作用，例如将氧气输送到全身器官。芬顿反应是铁与过氧化氢之间的反应，会生成羟基自由基，这种自由基具有高度反应性和对活细胞的高度毒性。“铁死亡”是一种程序性细胞死亡，其中芬顿反应密切参与，最近受到了广泛关注。此外，芬顿反应在医学和营养领域的各种应用也有报道，如癌症治疗或杀菌。在这里，通过芬顿反应的基础和实际信息以及最近的报告，综述了最近人们对铁的有用性及其生物学相关性的日益关注。
