Sutkowy Paweł, Czeleń Przemysław
Department of Medical Biology and Biochemistry, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Karlowicza 24, 85-092 Bydgoszcz, Poland.
Department of Physical Chemistry, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, Kurpinskiego 5, 85-096 Bydgoszcz, Poland.
Biomedicines. 2025 May 9;13(5):1149. doi: 10.3390/biomedicines13051149.
Malignant neoplasms constitute a substantial health concern for the human population, currently ranking as the second leading cause of mortality worldwide. In 2022, approximately 10 million deaths were attributable to cancer, and projections estimate that this number will rise to 35 million in 2050. Consequently, the development of effective cancer treatments and prevention strategies remains a primary focus of medical research. In this context, the impacts on the redox balance are being considered. The objective of this study was to present the current knowledge on oxidation and reduction processes in cancer. This review discloses the intricate and multifaceted interplay of oxidoreductive systems during carcinogenesis, which engenders discordant findings in the domain of tumor prevention and treatment. This study also examines the controversies surrounding the use of antioxidants, including their impact on other therapeutic interventions. The review offers a comprehensive overview of the existing knowledge on the subject, concluding that personalized and precise anticancer therapies targeting the redox processes can serve as both effective diagnostic and therapeutic tools.
恶性肿瘤是人类健康的重大问题，目前是全球第二大死因。2022年，约1000万人死于癌症，预计到2050年这一数字将增至3500万。因此，开发有效的癌症治疗方法和预防策略仍然是医学研究的主要重点。在此背景下，人们正在考虑氧化还原平衡的影响。本研究的目的是介绍目前关于癌症中氧化和还原过程的知识。这篇综述揭示了致癌过程中氧化还原系统复杂而多方面的相互作用，这在肿瘤预防和治疗领域产生了不一致的结果。本研究还探讨了围绕抗氧化剂使用的争议，包括它们对其他治疗干预的影响。该综述全面概述了该主题的现有知识，得出结论认为，针对氧化还原过程的个性化和精确抗癌疗法可作为有效的诊断和治疗工具。
