Synthesis of -Substituted Iminosugar -Glycosides and Evaluation as Promising -Glucosidase Inhibitors.

A series of -substituted iminosugar -glycosides were synthesized and tested for -glucosidase inhibition. The results suggested that is a promising and potent -glucosidase inhibitor. Enzymatic kinetic assays indicated that compound may be classified as an uncompetitive inhibitor. The study of structure-activity relationships of those iminosugars provided a starting point for the discovery of new -glucosidase inhibitors.