合成 -取代亚氨基糖 -糖苷，并评估其作为有前途的 -葡萄糖苷酶抑制剂。
Synthesis of -Substituted Iminosugar -Glycosides and Evaluation as Promising -Glucosidase Inhibitors.
机构信息
Natural Products Research Centre, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
出版信息
Molecules. 2022 Aug 27;27(17):5517. doi: 10.3390/molecules27175517.
A series of -substituted iminosugar -glycosides were synthesized and tested for -glucosidase inhibition. The results suggested that is a promising and potent -glucosidase inhibitor. Enzymatic kinetic assays indicated that compound may be classified as an uncompetitive inhibitor. The study of structure-activity relationships of those iminosugars provided a starting point for the discovery of new -glucosidase inhibitors.
一系列 -取代的亚氨基糖 -糖苷被合成并测试其对 -葡萄糖苷酶的抑制作用。结果表明， 是一种有前途和有效的 -葡萄糖苷酶抑制剂。酶动力学测定表明，化合物 可能属于非竞争性抑制剂。对这些亚氨基糖的构效关系研究为发现新的 -葡萄糖苷酶抑制剂提供了起点。
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