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L. 及其相关物种：液相色谱 - 质谱联用图谱以及抗糖尿病、抗氧化、抗炎、抗菌和抗癌潜力

L. and Related Species: LC-MS Profiles and Antidiabetic, Antioxidant, Anti-Inflammatory, Antibacterial and Anticancer Potential.

作者信息

Friščić Maja, Petlevski Roberta, Kosalec Ivan, Madunić Josip, Matulić Maja, Bucar Franz, Hazler Pilepić Kroata, Maleš Željan

机构信息

Department of Pharmaceutical Botany, Faculty of Pharmacy and Biochemistry, University of Zagreb, Schrottova 39, HR-10000 Zagreb, Croatia.

Department of Medical Biochemistry and Hematology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Domagojeva 2, HR-10000 Zagreb, Croatia.

出版信息

Pharmaceuticals (Basel). 2022 Apr 21;15(5):506. doi: 10.3390/ph15050506.

DOI:10.3390/ph15050506
PMID:35631332
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9146695/
Abstract

Species from the genus L. have been used as healing agents for various ailments, with utilization of L. being most frequently reported. The aim of this study was to evaluate the antidiabetic, antioxidant, anti-inflammatory, antibacterial and anticancer potential of and three related species, Lapeyr., L. and (Podp.) O.Schwarz, in relation to their phytochemical compositions. Globularin and verbascoside were identified using LC-PDA-ESI-MS as the major metabolites of with known biological activities. demonstrated the greatest α-glucosidase inhibitory activity and DPPH radical scavenging activity (IC = 17.25 μg/mL), while its anti-inflammatory activity was not significantly different from those of related species. All investigated species showed considerable antibacterial activity against methicillin-resistant in the broth microdilution method (MIC = 1.42-3.79 mg/mL). also showed antibacterial activities against (MIC = 1.42 mg/mL), (MIC = 1.89 mg/mL), (MIC = 2.84 mg/mL) and (MBC = 5.68 mg/mL). , and showed greater anticancer potential than . Obtained results indicate investigated species could serve as sources of diverse bioactive molecules, with having the greatest antibacterial potential.

摘要

L.属的物种已被用作治疗各种疾病的药物，其中对L.的利用报道最为频繁。本研究的目的是评估L.以及三个相关物种Lapeyr.、L.和(Podp.) O.Schwarz的抗糖尿病、抗氧化、抗炎、抗菌和抗癌潜力，并分析它们的植物化学成分。使用LC-PDA-ESI-MS鉴定出globularin和毛蕊花糖苷是L.具有已知生物活性的主要代谢产物。L.表现出最大的α-葡萄糖苷酶抑制活性和DPPH自由基清除活性（IC = 17.25 μg/mL），而其抗炎活性与相关物种无显著差异。在肉汤微量稀释法中，所有研究的物种对耐甲氧西林金黄色葡萄球菌均表现出相当的抗菌活性（MIC = 1.42 - 3.79 mg/mL）。L.对大肠杆菌（MIC = 1.42 mg/mL）、肺炎克雷伯菌（MIC = 1.89 mg/mL）、铜绿假单胞菌（MIC = 2.84 mg/mL）和白色念珠菌（MBC = 5.68 mg/mL）也表现出抗菌活性。Lapeyr.、L.和L.比L.表现出更大的抗癌潜力。所得结果表明，所研究的L.物种可作为多种生物活性分子的来源，其中L.具有最大的抗菌潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77e2/9146695/4681b8b3de52/pharmaceuticals-15-00506-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77e2/9146695/a90db25280d7/pharmaceuticals-15-00506-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77e2/9146695/553c5c0c5139/pharmaceuticals-15-00506-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77e2/9146695/38a1018c9e96/pharmaceuticals-15-00506-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77e2/9146695/00393e0df548/pharmaceuticals-15-00506-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77e2/9146695/f0ff4353fa81/pharmaceuticals-15-00506-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77e2/9146695/4681b8b3de52/pharmaceuticals-15-00506-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77e2/9146695/a90db25280d7/pharmaceuticals-15-00506-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77e2/9146695/553c5c0c5139/pharmaceuticals-15-00506-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77e2/9146695/38a1018c9e96/pharmaceuticals-15-00506-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77e2/9146695/00393e0df548/pharmaceuticals-15-00506-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77e2/9146695/f0ff4353fa81/pharmaceuticals-15-00506-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77e2/9146695/4681b8b3de52/pharmaceuticals-15-00506-g006.jpg

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