相关变应原对人外周血淋巴细胞体外自发产生黑麦Ⅰ组特异性IgE抗体的抑制作用。

Suppression by relevant allergen of the spontaneous in vitro production of rye group I specific IgE antibodies by human peripheral blood lymphocytes.

作者信息

Mourad W, Pelletier G, Hébert J

出版信息

Clin Exp Immunol. 1987 Feb;67(2):391-7.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1542591/

Abstract

The production in vitro of rye Group I specific IgE antibodies (rye I specific IgE Ab) by human peripheral blood lymphocytes (PBL) was examined. A sensitive enzyme-linked immunosorbent assay was developed which allowed the detection of rye I specific IgE Ab without interference from other immunoglobulin classes. A significant net synthesis of rye I specific IgE Ab by PBL from atopic subjects was detected only during the pollen season, which could not be observed with PBL from non-atopic donors whenever tested. This active synthesis in vitro of IgE antibodies by PBL from atopic patients in season was suppressed when PBL were pre-incubated with the relevant antigen. Furthermore, we are reporting data suggesting an inhibition of the passive release of preformed rye I specific IgE Ab from cells by the specific allergen.

摘要

检测了人外周血淋巴细胞（PBL）体外产生黑麦Ⅰ组特异性IgE抗体（黑麦Ⅰ特异性IgE Ab）的情况。开发了一种灵敏的酶联免疫吸附测定法，该方法可检测黑麦Ⅰ特异性IgE Ab，而不受其他免疫球蛋白类别的干扰。仅在花粉季节检测到特应性受试者的PBL有显著的黑麦Ⅰ特异性IgE Ab净合成，无论何时检测，非特应性供体的PBL均未观察到这种情况。当PBL与相关抗原预孵育时，特应性患者在花粉季节的PBL体外这种IgE抗体的活性合成受到抑制。此外，我们报告的数据表明，特异性变应原可抑制细胞中预先形成的黑麦Ⅰ特异性IgE Ab的被动释放。

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本文引用的文献

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In vitro synthesis of IgE by human peripheral blood leucocytes: relationship to serum titre of leucocyte donor.人外周血白细胞体外合成IgE：与白细胞供体血清滴度的关系。

Clin Exp Immunol. 1981 Mar;43(3):458-62.

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Human IgE synthesis in vitro: a reassessment.体外人IgE合成：重新评估

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In vitro production of IgE by human peripheral blood mononuclear cells. IV. Modulation by allergen of the spontaneous IgE antibody biosynthesis.人外周血单个核细胞体外产生IgE。IV. 变应原对自发性IgE抗体生物合成的调节作用

Clin Exp Immunol. 1982 Jul;49(1):185-92.

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Human IgE, IgG and IgE antibody synthesis in vitro.

Int Arch Allergy Appl Immunol. 1980;63(2):129-38. doi: 10.1159/000232618.

6

Subpopulations of circulating B cells and regulatory T cells involved in in vitro immunoglobulin E production in atopic patients with elevted serum immunoglobulin E.血清免疫球蛋白E升高的特应性患者中参与体外免疫球蛋白E产生的循环B细胞和调节性T细胞亚群。

J Clin Invest. 1980 Jun;65(6):1457-68. doi: 10.1172/JCI109810.

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IgE production in vitro by human blood mononuclear cells: a comparison between atopic and nonatopic subjects.人血单核细胞体外产生IgE：特应性和非特应性受试者的比较。

J Allergy Clin Immunol. 1983 Mar;71(3):324-30. doi: 10.1016/0091-6749(83)90087-8.

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The regulatory effect of histamine on the immune response. II. Effect on the in vitro IGG synthesis.组胺对免疫反应的调节作用。II. 对体外IgG合成的影响。

Cell Immunol. 1981 Mar 1;58(2):366-71. doi: 10.1016/0008-8749(81)90230-6.

9

In vitro production of IgE by human peripheral blood mononuclear cells. I. Rate of IgE biosynthesis.人外周血单个核细胞体外产生IgE。I. IgE生物合成速率。

Clin Exp Immunol. 1980 Oct;42(1):167-74.

10

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J Biol Chem. 1970 Jun;245(12):3059-65.

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