Romagnani S, Maggi E, Del Prete G F, Almerigogna F, Biagiotti R, Giudizi M G, Ricci M
Clin Exp Immunol. 1982 Jul;49(1):185-92.
Peripheral blood lymphocytes (PBL) from a proportion of grass-sensitive patients, studied during or immediately after the grass pollination period, showed spontaneous production in vitro of grass-specific IgE antibody, whereas PBL from atopic patients sensitive to allergens other than grass pollens or non-atopic individuals did not. Pre-incubation of IgE antibody producing PBL from grass-sensitive patients with minute amounts of a mixed grass pollen (MGP) extract or Rye grass antigen Group I (Rye I) usually resulted in a reduction of the spontaneous production in vitro of IgE protein and in a marked inhibition of the spontaneous production in vitro of grass-specific IgE antibody. This antigen-specific inhibition was not mediated by T lymphocytes, but it was apparently due to a signal directly delivered by antigen to the spontaneously IgE antibody producing cells. The results support the concept that the activity of cells responsible for the persistent IgE antibody formation in vitro in atopic patients can be modulated by antigen.
在草授粉期或授粉期刚结束时对一部分对草敏感的患者的外周血淋巴细胞（PBL）进行研究，发现其在体外能自发产生草特异性IgE抗体，而对草花粉以外的过敏原敏感的特应性患者或非特应性个体的PBL则不能。用微量混合草花粉（MGP）提取物或黑麦草抗原I组（黑麦I）对来自对草敏感患者的产生IgE抗体的PBL进行预孵育，通常会导致体外IgE蛋白自发产生减少，并显著抑制草特异性IgE抗体的体外自发产生。这种抗原特异性抑制不是由T淋巴细胞介导的，而是显然由于抗原直接向自发产生IgE抗体的细胞传递信号所致。这些结果支持这样一种概念，即特应性患者体外持续形成IgE抗体的细胞活性可被抗原调节。
