Faculty of Pharmacy, European University Cyprus, Nicosia, Cyprus.
Department of Radiopharmacy, Faculty of Pharmacy, Ege University, Izmir, Turkey.
Curr Drug Deliv. 2023;20(9):1288-1313. doi: 10.2174/1567201819666220907124040.
Currently, there is ongoing research in the pharmaceutical technology field to develop innovative drug delivery systems with improved therapeutic efficacy.
Although there is a high need for new drug molecules, most scientists focus on the advancement of novel pharmaceutical formulations since the present excipients lack important properties such as low release rate leading to repeated dosing. Aside from this, pharmaceutical technologists aim to develop drug formulations that can target specific organs and tissues, lowering the possibility of adverse effects.
This review aims to cover the different polymer-based gel types, the development and characterization methods, as well as applications thereof. Finally, the recent advancements and future perspectives focusing on radiolabeled gels will be addressed.
In the last decades, polymer based pharmaceutical gels have shown attractive properties and therefore have raised the attention of pharmaceutical scientists. Gels are either chemically or physically cross-linked networks that can absorb fluids such as water (hydrogels), oil (organogels) and even air(aerogels). A variety of polymers, either synthetic or natural, have been employed as components for the gels. Stimuli-responsive gels based on stimuli-sensitive polymers are among the most studied gel class of last years.
The use of polymer-based gels as drug delivery systems would be beneficial for targeting numerous diseases.
目前，制药技术领域正在进行研究，以开发具有改善治疗效果的创新药物传递系统。
尽管对新的药物分子有很高的需求，但大多数科学家专注于新型药物制剂的开发，因为目前的赋形剂缺乏低释放率等重要特性，导致需要重复给药。除此之外，制药技术人员还致力于开发可以靶向特定器官和组织的药物制剂，降低不良反应的可能性。
本综述旨在涵盖不同的基于聚合物的凝胶类型、开发和表征方法，以及它们的应用。最后，将讨论最近的进展和关注放射性标记凝胶的未来展望。
在过去的几十年中，基于聚合物的药物凝胶表现出了有吸引力的特性，因此引起了制药科学家的关注。凝胶是化学或物理交联的网络，可以吸收水（水凝胶）、油（有机凝胶）甚至空气（气凝胶）等液体。各种聚合物，无论是合成的还是天然的，都被用作凝胶的组成部分。基于刺激响应性聚合物的刺激响应性凝胶是近年来研究最多的凝胶类之一。
将基于聚合物的凝胶用作药物传递系统将有益于针对多种疾病。
