School of Public Health, Medical College of Soochow University, Suzhou, China.
School of Public Health, Fudan University, 130 Dong An Road, Shanghai, 200032, China.
Eur J Health Econ. 2023 Aug;24(6):885-893. doi: 10.1007/s10198-022-01523-0. Epub 2022 Sep 9.
To compare measurement properties of the utility scores derived from various country-specific value sets of EQ-5D-5L (5L) and EORTC QLU-C10D (10D) in gastric cancer patient.
The study used cross-sectional data of 243 Chinese gastric cancer patients who completed both 5L and EORTC QLQ-C30. Utility score of QLU-C10D is generated from all the available QLU-C10D value sets currently; the score of 5L is derived from the corresponding 5L value sets for the countries with both the 5L and QLU-C10D value sets and the Chinese 5L value set. Convergent validity was evaluated by testing their correlations with the VAS score. Known-group validity was assessed by comparing the utility scores the patients with different severities. Their relative efficiency (RE) was also compared.
Correlation coefficient of 5L and QLU-C10D utility scores with VAS ranged from 0.54 to 0.59, and 0.55 to 0.63, respectively. Both the utility scores were in general able to discriminate the patients with different severities; and 5L utility score had higher RE in the majority of known-groups.
EQ-5D-5L and QLU-C10D utility scores were different and, thus, non-swappable. They possess similar convergent validity and known-group validity; while EQ-5D-5L scores may have better discriminative power.
比较源于各种特定国家 EQ-5D-5L（5L）和 EORTC QLQ-C10D（10D）效用评分的测量特性，以评估胃癌患者。
本研究使用了 243 名中国胃癌患者的横断面数据，这些患者均完成了 5L 和 EORTC QLQ-C30 量表的填写。QLU-C10D 的效用评分是从目前所有可用的 QLU-C10D 价值集生成的；5L 的评分是从具有 5L 和 QLU-C10D 价值集以及中国 5L 价值集的国家的相应 5L 价值集推导而来的。通过测试与 VAS 评分的相关性来评估收敛有效性。通过比较不同严重程度患者的效用评分来评估已知组的有效性。还比较了它们的相对效率（RE）。
5L 和 QLU-C10D 效用评分与 VAS 的相关系数分别为 0.54 至 0.59，0.55 至 0.63。这两个效用评分通常都能够区分不同严重程度的患者；并且在大多数已知组中，5L 效用评分的 RE 更高。
EQ-5D-5L 和 QLU-C10D 的效用评分不同，因此不可互换。它们具有相似的收敛有效性和已知组有效性；而 EQ-5D-5L 评分可能具有更好的区分能力。
