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环境中常见的家用和个人护理产品成分的污染状况及其潜在内分泌干扰性。

Environmental contamination status with common ingredients of household and personal care products exhibiting endocrine-disrupting potential.

机构信息

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000, Ljubljana, Slovenia.

Department of Clinical Biochemistry, Faculty of Pharmacy, University of Ljubljana, 1000, Ljubljana, Slovenia.

出版信息

Environ Sci Pollut Res Int. 2022 Oct;29(49):73648-73674. doi: 10.1007/s11356-022-22895-z. Epub 2022 Sep 9.

Abstract

The continuous use of household and personal care products (HPCPs) produces an immense amount of chemicals, such as parabens, bisphenols, benzophenones and alkylphenol ethoxylates, which are of great concern due to their well-known endocrine-disrupting properties. These chemicals easily enter the environment through man-made activities, thus contaminating the biota, including soil, water, plants and animals. Thus, on top of the direct exposure on account of their presence in HPCPs, humans are also susceptible to secondary indirect exposure attributed to the ubiquitous environmental contamination. The aim of this review was therefore to examine the sources and occurrence of these noteworthy contaminants (i.e. parabens, bisphenols, benzophenones, alkylphenol ethoxylates), to summarise the available research on their environmental presence and to highlight their bioaccumulation potential. The most notable environmental contaminants appear to be MeP and PrP among parabens, BPA and BPS among bisphenols, BP-3 among benzophenones and NP among alkylphenols. Their maximum detected concentrations in the environment are mostly in the range of ng/L, while in human tissues, their maximum concentrations achieved μg/L due to bioaccumulation, with BP-3 and nonylphenol showing the highest potential to bioaccumulate. Finally, of another great concern is the fact that even the unapproved parabens and benzophenones have been detected in the environment.

摘要

家用和个人护理产品(HPCPs)的持续使用会产生大量的化学物质,如对羟基苯甲酸酯、双酚类、二苯甲酮和烷基酚聚氧乙烯醚等,由于其众所周知的内分泌干扰特性,这些化学物质引起了极大的关注。这些化学物质很容易通过人为活动进入环境,从而污染包括土壤、水、植物和动物在内的生物群。因此,除了因为它们存在于 HPCPs 中而直接暴露外,人类还容易受到由于无处不在的环境污染而产生的二次间接暴露。因此,本次综述的目的是检查这些值得关注的污染物(即对羟基苯甲酸酯、双酚类、二苯甲酮、烷基酚聚氧乙烯醚)的来源和出现情况,总结关于它们在环境中存在的现有研究,并强调它们的生物累积潜力。最值得注意的环境污染物似乎是对羟基苯甲酸酯中的 MeP 和 PrP、双酚类中的 BPA 和 BPS、二苯甲酮中的 BP-3 和烷基酚中的 NP。它们在环境中的最大检测浓度大多在 ng/L 范围内,而在人体组织中,由于生物累积,它们的最大浓度达到了μg/L,其中 BP-3 和壬基酚具有最高的生物累积潜力。最后,另一个令人担忧的事实是,即使是未经批准的对羟基苯甲酸酯和二苯甲酮也已经在环境中被检测到。

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