Tsvetkova A V, Koneva E S, Kostenko A A, Bisheva D R, Sidyakina I V, Konev S M, Zhumanova E N, Illarionov V E, Shestakov A V
Sechenov First Moscow State Medical University, Moscow, Russia.
Group of companies «MEDSI», Otradnoe, Russia.
Vopr Kurortol Fizioter Lech Fiz Kult. 2022;99(4. Vyp. 2):22-29. doi: 10.17116/kurort20229904222.
To evaluate the effectiveness and safety of ozone therapy in rehabilitation of patients with previous COVID-19.
A randomized controlled clinical trial included 51 patients aged 29 - 78 years with SARS-CoV-2 pneumonia (J12.8). Patients were divided into 3 comparable groups depending on the complex of rehabilitation. In the first (control) group (=17), a 10-day course included daily breathing exercises and physiotherapy for the lungs (drug electrophoresis and low-frequency magnetotherapy). In the second (main) group (=18), rehabilitation was combined with daily intravenous infusions of ozonized saline with ozone concentration of 2.0 mg/l within 5 days with subsequent standard rehabilitation. In the third group (=16), patients received 5 ozone therapy procedures every other day. To determine the effectiveness and safety of systemic ozone therapy in rehabilitation of patients with previous COVID-19, we analyzed oxygen saturation, laboratory data (D-dimer and C-reactive protein), need for oxygen support before and after rehabilitation course. Complaints and quality of life throughout the rehabilitation program were assessed using the EQ-5D questionnaire.
All patients had positive changes of all parameters. There were no adverse reactions throughout the rehabilitation program and 2 months later. We observed higher effectiveness of rehabilitation with systemic ozone therapy. Moreover, daily ozone therapy had a better effect on laboratory parameters compared to ozone therapy every other day.
Ozone therapy is safe and effective in complex rehabilitation of patients with previous COVID-19. Further studies of large samples are needed to determine indications and appropriate criteria for this rehabilitation program.
评估臭氧疗法对既往感染新型冠状病毒肺炎患者康复的有效性和安全性。
一项随机对照临床试验纳入了51例年龄在29至78岁之间的新型冠状病毒肺炎（J12.8）患者。根据康复方案，将患者分为3个可比组。第一组（对照组，n = 17），进行为期10天的疗程，包括每日呼吸锻炼和肺部物理治疗（药物电泳和低频磁疗）。第二组（主要组，n = 18），康复治疗结合每日静脉输注臭氧浓度为2.0 mg/l的臭氧生理盐水，持续5天，随后进行标准康复治疗。第三组（n = 16），患者每隔一天接受5次臭氧治疗。为了确定全身臭氧疗法对既往感染新型冠状病毒肺炎患者康复的有效性和安全性，我们分析了康复疗程前后的血氧饱和度、实验室数据（D-二聚体和C反应蛋白）以及对氧气支持的需求。使用EQ-5D问卷评估整个康复计划中的患者主诉和生活质量。
所有患者的各项参数均有积极变化。在整个康复计划期间及2个月后均未出现不良反应。我们观察到全身臭氧疗法的康复效果更佳。此外，与隔日臭氧疗法相比，每日臭氧疗法对实验室参数的影响更好。
臭氧疗法对既往感染新型冠状病毒肺炎患者的综合康复是安全有效的。需要进一步进行大样本研究以确定该康复方案的适应症和合适标准。
