First Department of Medicine, Department Infectious Diseases, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.
Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.
Cell Immunol. 2022 Oct;380:104589. doi: 10.1016/j.cellimm.2022.104589. Epub 2022 Aug 13.
The pulp of human teeth contains a population of self-renewing stem cells that can regulate the functions of immune cells. When applied to patients, these cells can protect tissues from damage by excessive inflammation. We confirm that dental pulp cells effectively inhibit the proliferation and activation of cytotoxic T cells in vitro, and show that they carry high levels of CD73, a key enzyme in the conversion of pro-inflammatory extracellular ATP to immunosuppressive adenosine. Given their accessibility and abundance, as well as their potential for allogeneic administration, dental pulp cells provide a valuable source for immunomodulatory therapy.
牙髓中的细胞群包含自我更新的干细胞，可以调节免疫细胞的功能。将这些细胞应用于患者体内时，它们可以保护组织免受过度炎症的损伤。我们证实牙髓细胞可有效抑制细胞毒性 T 细胞的体外增殖和激活，并表明它们携带高水平的 CD73，这是将促炎细胞外 ATP 转化为免疫抑制腺苷的关键酶。鉴于牙髓细胞易于获取且丰富，并且具有同种异体给药的潜力，因此它们为免疫调节治疗提供了有价值的来源。
