Fu Jing, Li Xigong, Jin Feilu, Dong Yanzhao, Zhou Haiying, Alhaskawi Ahmad, Wang Zewei, Lai Jingtian, Yao Chengjun, Ezzi Sohaib Hasan Abdullah, Kota Vishnu Goutham, Hasan Abdulla Hasan Abdulla Mohamed, Chen Bin, Lu Hui
Department of Stomatology, Affiliated Hangzhou Xixi Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Orthopedics, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Front Neurol. 2023 Jan 11;13:1098857. doi: 10.3389/fneur.2022.1098857. eCollection 2022.
Peripheral nerve diseases are significantly correlated with severe fractures or trauma and surgeries, leading to poor life quality and impairment of physical and mental health. Human dental pulp stem cells (DPSCs) are neural crest stem cells with a strong multi-directional differentiation potential and proliferation capacity that provide a novel cell source for nerve regeneration. DPSCs are easily extracted from dental pulp tissue of human permanent or deciduous teeth. DPSCs can express neurotrophic and immunomodulatory factors and, subsequently, induce blood vessel formation and nerve regeneration. Therefore, DPSCs yield valuable therapeutic potential in the management of peripheral neuropathies. With the purpose of summarizing the advances in DPSCs and their potential applications in peripheral neuropathies, this article reviews the biological characteristics of DPSCs in association with the mechanisms of peripheral nerve regeneration.
周围神经疾病与严重骨折、创伤及手术显著相关，导致生活质量下降及身心健康受损。人牙髓干细胞（DPSCs）是具有强大多向分化潜能和增殖能力的神经嵴干细胞，为神经再生提供了一种新的细胞来源。DPSCs易于从人恒牙或乳牙的牙髓组织中提取。DPSCs可表达神经营养和免疫调节因子，随后诱导血管形成和神经再生。因此，DPSCs在周围神经病变的治疗中具有重要的治疗潜力。为了总结DPSCs的研究进展及其在周围神经病变中的潜在应用，本文综述了DPSCs的生物学特性以及周围神经再生的机制。
