Clinical Research Institute, First People's Hospital of Foshan, Foshan, 528000, China.
Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300192, China.
Biomaterials. 2022 Oct;289:121791. doi: 10.1016/j.biomaterials.2022.121791. Epub 2022 Sep 3.
Fenton reaction-based chemodynamic therapy is hardly a self-sufficient cancer treatment, due to its stringent reaction conditions, limited substrate concentration, and negative feedback from the tumor microenvironment. Herein, we synthesized a novel two-dimensional (2D) vanadium-based nanosheets (Vanadene, V NSs) with polyvalent surfaces (V/V), a very narrow band gap of 0.8 eV, and high biodegradability by a liquid-phase exfoliation strategy. The polyvalent surface endowed its multiple capabilities to modulate TME through GSH consumption and O production via V and to catalyze a Fenton-like reaction to produce ·OH under a mild condition via V. In addition, efficient energy conversions including near-infrared (NIR)-thermal conversion (photothermal therapy, PTT) and NIR-electron conversion (photodynamic therapy, PDT) were ensured by the narrow band gap, in which NIR-thermal conversion enhanced the Fenton-like reaction activity through accelerating ionization while NIR-electron conversion catalyzed the conversion of O to ·O for further breaking redox homeostasis. Moreover, V NSs-based nanocatalyst can be slowly degraded into non-toxic species, enabling it to be innocuously eliminated from the body after completing tumor eradication by single drug injection and single NIR irradiation. Therefore, this study provides new insights into a universal nanoplatform for NIR-enhanced combination cancer therapy, highlighting the utility of 2D V NSs in the field of biomedicine.
基于芬顿反应的化学动力学疗法由于其严格的反应条件、有限的底物浓度以及肿瘤微环境的负反馈，几乎不能作为一种自给自足的癌症治疗方法。在此，我们通过液相剥离策略合成了一种具有多价表面（V/V）、非常窄的带隙为 0.8 eV 和高生物降解性的新型二维（2D）钒基纳米片（Vanadene，V NSs）。多价表面赋予其多种能力，通过 V 消耗 GSH 和产生 O 来调节 TME，并通过 V 催化类芬顿反应在温和条件下产生·OH。此外，通过窄带隙确保了有效的能量转换，包括近红外（NIR）-热转换（光热疗法，PTT）和 NIR-电子转换（光动力疗法，PDT），其中 NIR-热转换通过加速离子化增强类芬顿反应活性，而 NIR-电子转换则催化 O 向·O 的转化，以进一步打破氧化还原平衡。此外，基于 V NSs 的纳米催化剂可以缓慢降解为无毒物质，使其能够在通过单次药物注射和单次 NIR 照射完成肿瘤清除后从体内无害消除。因此，本研究为 NIR 增强的联合癌症治疗提供了新的见解，突显了 2D V NSs 在生物医学领域的应用潜力。
