School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China; Academy of Contemporary Food Engineering, South China University of Technology, Guangzhou Higher Education Mega Center, Guangzhou 510006, China; Engineering and Technological Research Centre of Guangdong Province on Intelligent Sensing and Process Control of Cold Chain Foods, & Guangdong Province Engineering Laboratory for Intelligent Cold Chain Logistics Equipment for Agricultural Products, Guangzhou Higher Education Mega Centre, Guangzhou 510006, China.
School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China; Academy of Contemporary Food Engineering, South China University of Technology, Guangzhou Higher Education Mega Center, Guangzhou 510006, China; Engineering and Technological Research Centre of Guangdong Province on Intelligent Sensing and Process Control of Cold Chain Foods, & Guangdong Province Engineering Laboratory for Intelligent Cold Chain Logistics Equipment for Agricultural Products, Guangzhou Higher Education Mega Centre, Guangzhou 510006, China; Food Refrigeration and Computerized Food Technology (FRCFT), Agriculture and Food Science Centre, University College Dublin, National University of Ireland, Belfield, Dublin 4, Ireland(1).
Spectrochim Acta A Mol Biomol Spectrosc. 2023 Jan 5;284:121817. doi: 10.1016/j.saa.2022.121817. Epub 2022 Aug 30.
With the growing popularity of the non-destructive technique, surface-enhanced Raman spectroscopy (SERS) demands a highly sensitive and reproducible plasmonic nanoparticles substrate. In this study, a novel bimetallic core-shell nanoparticles (Au@Ag@mSiONP) substrate consisting of a gold core, silver shell, and a mesoporous silica coating was synthesized. The mesoporous coating structure was created by employing template molecules such as surfactant and their subsequent removal allowing selective screening based on the size of analyte molecules. Results showed that the plasmonic substrate could selectively enhance small molecules by preventing large macromolecules to reach the exciting zone of the substrate core, achieving the detection of chloramphenicol in milk samples with a detection limit of 6.68 × 10 M. Moreover, the mesoporous coating provided additional stability to the Au@Ag nanoparticles, leading to the reusability of the substrate. Thus, this work offered a simple and smart Au@Ag@mSiONP substrate for effective SERS detection of analytes.
随着非破坏性技术的日益普及，表面增强拉曼光谱（SERS）需要一种高度灵敏和可重复的等离子体纳米粒子基底。在这项研究中，合成了一种由金核、银壳和介孔硅涂层组成的新型双金属核壳纳米粒子（Au@Ag@mSiONP）基底。介孔涂层结构是通过使用表面活性剂等模板分子以及随后去除模板分子来创建的，允许根据分析物分子的大小进行选择性筛选。结果表明，等离子体基底可以通过阻止大分子到达基底核心的激发区来选择性地增强小分子，从而实现对牛奶样品中氯霉素的检测，检测限为 6.68×10^-10 M。此外，介孔涂层为 Au@Ag 纳米粒子提供了额外的稳定性，从而实现了基底的可重复使用。因此，这项工作提供了一种简单而智能的 Au@Ag@mSiONP 基底，可有效用于分析物的 SERS 检测。
