Annu Int Conf IEEE Eng Med Biol Soc. 2022 Jul;2022:3093-3099. doi: 10.1109/EMBC48229.2022.9871812.
Biphasic pulsatile stimulation is the present standard for neural prosthetic use, and it is used to understand connectivity and functionality of the brain in brain mapping studies. While pulses have been shown to drive behavioral changes, such as biasing decision making, they have deficits. For example, cochlear implants restore hearing but lack the ability to restore pitch perception. Recent work shows that pulses produce artificial synchrony in networks of neurons and non-linear changes in firing rate with pulse amplitude. Studies also show galvanic stimulation, delivery of current for extended periods of time, produces more naturalistic behavioral responses than pulses. In this paper, we use a winner-take-all decision-making network model to investigate differences between pulsatile and galvanic stimulation at the single neuron and network level while accurately modeling the effects of pulses on neurons for the first time. Results show pulses bias spike timing and make neurons more resistive to natural network inputs than galvanic stimulation at an equivalent current amplitude. Clinical Relevance- This establishes that pulsatile stimulation may disrupt natural spike timing and network-level interactions while certain parameterizations of galvanic stimulation avoid these effects and can drive network firing more naturally.
双相脉冲刺激是目前神经假体使用的标准，它被用于理解大脑连接和功能在脑映射研究。虽然脉冲已被证明可以驱动行为改变，如影响决策，但它们也存在缺陷。例如，人工耳蜗植入物可以恢复听力，但缺乏恢复音高感知的能力。最近的研究表明，脉冲在神经元网络中产生人工同步，并且随着脉冲幅度的变化，放电率呈非线性变化。研究还表明，电流持续时间较长的电流刺激比脉冲刺激产生更自然的行为反应。在本文中，我们使用一个赢家通吃决策网络模型来研究在单个神经元和网络层面上，脉冲刺激和电流刺激之间的差异，同时首次准确地模拟了脉冲对神经元的影响。结果表明，与电流刺激相比，脉冲刺激会改变神经元的放电时间，使其对自然网络输入的抵抗力增强。临床意义-这表明，脉冲刺激可能会破坏自然的放电时间和网络层面的相互作用，而电流刺激的某些参数化可以避免这些影响，并更自然地驱动网络放电。
