Zhejiang Changzheng Vocational and Technical College, Hangzhou, P. R. China.
Medicine (Baltimore). 2022 Sep 9;101(36):e30344. doi: 10.1097/MD.0000000000030344.
Obesity is characterized by excessive accumulation of adiposity and has been implicated in a strong predisposition to metabolic disorders and cancer, constituting one of the major public health issues worldwide. The formation of new mature adipocytes through differentiation of progenitor or precursor cells during adipogenesis can lead to the expansion of adipose tissue. Recent studies have revealed that the intrinsic risk of obesity arises not only through genetic variants but also through epigenetic predisposition. Enhancer of zeste homolog 2 (EZH2) is an enzymatic catalytic component of polycomb repressive complex 2 that acts as an epigenetic modulator in the regulation of gene expression. EZH2 can modulate the expression of its target genes by the trimethylation of Lys-27 in histone 3 or methylation of non-histone proteins. Emerging evidence has shown the important role played by EZH2 in adipogenesis and obesity. This review provides the latest knowledge about the involvement of EZH2 in the process of adipogenesis and obesity involving adipocyte differentiation, extract key concepts, and highlight open questions toward a better understanding of EZH2 function and the molecular mechanisms underlying obesity.
肥胖症的特征是脂肪过多积累，并与代谢紊乱和癌症的强烈易感性有关，是全球主要的公共卫生问题之一。在脂肪生成过程中，祖细胞或前体细胞的分化会导致新的成熟脂肪细胞的形成，从而导致脂肪组织的扩张。最近的研究表明，肥胖的内在风险不仅源于遗传变异，还源于表观遗传倾向。EZH2（ Enhancer of zeste homolog 2 ）是多梳抑制复合物 2 的酶催化组成部分，作为一种表观遗传调节剂，在基因表达的调控中发挥作用。EZH2 可以通过组蛋白 3 上的赖氨酸 27 三甲基化或非组蛋白的甲基化来调节其靶基因的表达。新出现的证据表明，EZH2 在脂肪生成和肥胖中起着重要作用。本综述提供了关于 EZH2 参与脂肪生成和肥胖的最新知识，包括脂肪细胞分化，提取关键概念，并强调了对 EZH2 功能和肥胖相关分子机制的更好理解的开放性问题。
