West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China; International Institute of Spatial Lifecourse Epidemiology (ISLE), Hong Kong, China.
Carver College of Medicine, University of Iowa, Iowa City, IA, USA; International Institute of Spatial Lifecourse Epidemiology (ISLE), Hong Kong, China.
J Diabetes Complications. 2021 Mar;35(3):107817. doi: 10.1016/j.jdiacomp.2020.107817. Epub 2020 Nov 26.
With the increasing prevalence of obesity, there is a growing awareness of its impact on infectious diseases. In past epidemics of influenza A and Middle East respiratory syndrome (MERS) coronavirus, obesity has been identified as a risk factor influencing the severity of illness in infected persons. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for a large number of deaths and health damages worldwide. Increasing numbers of reports have linked obesity to more severe COVID-19 disease and death. This review focuses on the impact of obesity on patients with COVID-19. We comprehensively analyzed the various mechanisms of obesity affecting the severity of the disease. In addition, on the basis of the vulnerability of people with obesity during the COVID-19 epidemic, we summarized both individual-level and hospital-level prevention and management measures for COVID-19 patients with obesity and discussed the impact of isolation on people with obesity.
随着肥胖症的日益流行，人们越来越意识到它对传染病的影响。在过去的甲型流感和中东呼吸综合征（MERS）冠状病毒流行中，肥胖已被确定为影响感染者疾病严重程度的一个危险因素。严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）在全球范围内导致了大量的死亡和健康损害。越来越多的报告将肥胖与更严重的 COVID-19 疾病和死亡联系起来。本综述重点关注肥胖对 COVID-19 患者的影响。我们全面分析了肥胖影响疾病严重程度的各种机制。此外，基于肥胖者在 COVID-19 流行期间的脆弱性，我们总结了肥胖 COVID-19 患者的个体和医院层面的预防和管理措施，并讨论了隔离对肥胖者的影响。
