Department of Neurosurgery, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.
Department of Neurosurgery, Sun Medical Center, Daejeon, Korea.
Medicine (Baltimore). 2022 Sep 9;101(36):e30373. doi: 10.1097/MD.0000000000030373.
The relationship between air pollutants, including fine particles (particulate matter [PM] < 10 μm and < 2.5 μm), and aneurysmal subarachnoid hemorrhage (SAH) has been inadequately studied, and the results remain inconclusive. In this study, we attempted to investigate the relationship between air pollutant levels and aneurysmal SAH.
Ninety-two patients diagnosed with aneurysmal SAH were retrospectively included in the study. Medical records were reviewed, and levels of pollutants, including those of sulfur dioxide (SO2), nitrogen dioxide (NO2), ozone (O3), carbon monoxide (CO), and PM with an aerodynamic diameter < 10 and 2.5 μm (PM10 and PM2.5), were collected from the open-source Air Korea website for a period of 4 days. Independent t-tests were conducted to identify the difference in the pollutant levels between the data obtained on the day of aneurysm rupture (D-0) and the other 3 days (D-7, D-2, and D-1).
A majority (40.2%) of the patients experienced aneurysm rupture during the fall season when the mean daily pollutant levels were 0.004 ± 0.001 (ppm, SO2), 0.517 ± 0.218 (ppm, CO), 0.02056 ± 0.012 (ppm, O3), 0.02628 ± 0.015 (ppm, NO2), 36.36957 ± 24.538 (μg/m3, PM10), and 19.75581 ± 13.494 (μg/m3, PM2.5), respectively. The level of NO2 was significantly higher on the day of aneurysm rupture (P = .035) than on the other days, while the levels of CO and O3 were nonsignificantly higher (P = .081, P = .055, respectively) on the day of aneurysm rupture than on the other days. There was no significant differences in the PM levels between the 4 days.
A relationship between PM levels and aneurysm rupture was not identified. Only the levels of classic air pollutant (CO, O3, and NO2) were higher on the aneurysm rupture day than on the other days.
包括细颗粒物（颗粒物<10μm 和<2.5μm）在内的空气污染物与蛛网膜下腔出血（SAH）之间的关系尚未得到充分研究，结果尚无定论。在这项研究中，我们试图探讨空气污染物水平与蛛网膜下腔出血的关系。
回顾性纳入 92 例诊断为蛛网膜下腔出血的患者。回顾病历，收集污染物水平，包括二氧化硫（SO2）、二氧化氮（NO2）、臭氧（O3）、一氧化碳（CO）和空气动力学直径<10μm 和 2.5μm 的颗粒物（PM10 和 PM2.5），来源于开源 Air Korea 网站，为期 4 天。进行独立样本 t 检验，以确定在动脉瘤破裂当天（D-0）与其他 3 天（D-7、D-2 和 D-1）的数据之间污染物水平的差异。
大多数（40.2%）患者在秋季发生动脉瘤破裂，此时每日平均污染物水平分别为 0.004±0.001（ppm，SO2）、0.517±0.218（ppm，CO）、0.02056±0.012（ppm，O3）、0.02628±0.015（ppm，NO2）、36.36957±24.538（μg/m3，PM10）和 19.75581±13.494（μg/m3，PM2.5）。在动脉瘤破裂当天，NO2 的水平明显高于其他天数（P=0.035），而 CO 和 O3 的水平在动脉瘤破裂当天与其他天数相比，差异无统计学意义（P=0.081，P=0.055）。4 天之间 PM 水平无显著差异。
未发现 PM 水平与动脉瘤破裂之间存在关系。只有经典空气污染物（CO、O3 和 NO2）的水平在动脉瘤破裂当天高于其他天数。
