Department of Pharmacy, Mianyang Central Hospital, Mianyang, P.R. China.
Department of Pharmacy, The First Affiliated Hospital of Chengdu Medical College, Clinical Medical College, Chengdu Medical College, Chengdu, P.R. China.
Medicine (Baltimore). 2022 Sep 9;101(36):e30516. doi: 10.1097/MD.0000000000030516.
To assess the influence of marital status on the survival of patients with nasopharyngeal carcinoma (NPC), we used the Surveillance, Epidemiology, and End Results (SEER) database to analyze 5477 patients who were diagnosed with NPC from 2004 to 2016.
Kaplan-Meier survival analysis and Cox proportional hazard regression were used to analyze the influence of marital status on cause-specific survival (CSS) and overall survival (OS). Subgroup analyses was used to assess the influence of marital status on CSS based on different factors.
For the 5477 patients, 61.5%, 22.4%, and 16.1% were married, single/unmarried, and separated/widowed/divorced, respectively. The separated/widowed/divorced group was more likely to be female (P < .001), had the highest proportion of elderly subjects (P < .001), were mostly Caucasian (P < .001), had pathological grade I/II (P < .001), were likely to undergo surgery (P = .032), and were registered in the northeast, north-central, and south (P < .001) regions. The 5-year CSS rates were 92.6%, 92.4%, and 85.1% in the married, single/unmarried, and separated/widowed/divorced groups, respectively (P < .001), and the 5-year OS rates were 60.7%, 54.6%, and 40.1%, respectively (P < .001).
Marital status is an independent prognostic factor of NPC. Separated/widowed/divorced patients had a significantly increased risk of NPC-related death (hazard ratio [HR] = 2.180, 95% confidence interval [CI] 1.721-2.757, P < .001) compared to married patients. The single/unmarried (P = .355) group had a CSS similar to that of the unmarried group. Marital status is an independent prognostic factor of survival in NPC patients. Separated/widowed/divorced status increases the risk of NPC mortality.
为了评估婚姻状况对鼻咽癌（NPC）患者生存的影响，我们使用监测、流行病学和最终结果（SEER）数据库分析了 2004 年至 2016 年间诊断为 NPC 的 5477 例患者。
采用 Kaplan-Meier 生存分析和 Cox 比例风险回归分析婚姻状况对特定原因生存（CSS）和总生存（OS）的影响。采用亚组分析评估婚姻状况对 CSS 的影响，基于不同因素。
在 5477 例患者中，分别有 61.5%、22.4%和 16.1%已婚、未婚和离异/丧偶。离异/丧偶组更可能为女性（P<0.001），老年患者比例最高（P<0.001），主要为白种人（P<0.001），病理分级 I/II 级（P<0.001），多接受手术（P=0.032），登记在东北部、中北部和南部（P<0.001）地区。已婚、未婚和离异/丧偶组的 5 年 CSS 率分别为 92.6%、92.4%和 85.1%（P<0.001），5 年 OS 率分别为 60.7%、54.6%和 40.1%（P<0.001）。
婚姻状况是 NPC 的独立预后因素。与已婚患者相比，离异/丧偶患者 NPC 相关死亡风险显著增加（风险比[HR]为 2.180，95%置信区间[CI]为 1.721-2.757，P<0.001）。未婚（P=0.355）组与未婚组的 CSS 相似。婚姻状况是 NPC 患者生存的独立预后因素。离异/丧偶状态增加 NPC 死亡率的风险。
