Xia Longjie, Lai Jianqin, Liu Xiangxia, Kong Fanbiao, Qiu Shenghui, Hu Huiqiong, Zhu Shaoliang, Cao Jie
Department of General Surgery, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China.
Department of General Surgery, Guangzhou First People's Hospital, Guangzhou, China.
Transl Cancer Res. 2023 Aug 31;12(8):1951-1962. doi: 10.21037/tcr-23-368. Epub 2023 Aug 28.
Neuroendocrine carcinoma of the breast (NECB) is a rare subtype of breast cancer, comprising only 0.1% to 5% of all breast cancer cases. Despite its rarity, it is important to gain a better understanding of the epidemiological, clinical, and prognostic features of NECB. The purpose of the study was to obtain population-based evaluations of the epidemiological and survival outcomes of NECB.
The data of patients with neuroendocrine carcinoma diagnosed and enrolled between 2000 and 2017 were obtained from the Surveillance, Epidemiology, and End Results (SEER) database. Descriptive statistical analyses were used to assess the distribution and tumor-related characteristics of these patients. Kaplan-Meier curves and univariate and multivariate Cox proportional risk models were used to analyze variables that might be associated with prognosis.
This study included 7,856 patients with neuroendocrine carcinoma. The median age of the patients was 64 years, and most of them were female, White, and diagnosed at ≥60 years old. The most common pathological type was neoplasm. Survival analysis indicated that there were significant differences in age, marital status, registration location, American Joint Committee on Cancer (AJCC) stage, breast subtype, surgery of primary tumor, and no cancer cause surgery patients with NECB. The results also indicated that treatment with surgery, including surgery of primary tumor, surgery combined with radiation, and no cancer cause surgery, were all effective in improving the prognosis compared with not providing surgical treatment.
In conclusion, NECB is a very rare lesion for which age, marital status, registration location, and surgery, AJCC stage, breast subtype were found to be independent prognostic factors.
乳腺神经内分泌癌（NECB）是一种罕见的乳腺癌亚型，仅占所有乳腺癌病例的0.1%至5%。尽管其罕见，但更好地了解NECB的流行病学、临床和预后特征很重要。本研究的目的是获得基于人群的NECB流行病学和生存结果评估。
从监测、流行病学和最终结果（SEER）数据库中获取2000年至2017年诊断并纳入的神经内分泌癌患者的数据。使用描述性统计分析来评估这些患者的分布和肿瘤相关特征。采用Kaplan-Meier曲线以及单变量和多变量Cox比例风险模型来分析可能与预后相关的变量。
本研究纳入了7856例神经内分泌癌患者。患者的中位年龄为64岁，大多数为女性、白人，且诊断时年龄≥60岁。最常见的病理类型是肿瘤。生存分析表明，NECB患者在年龄、婚姻状况、登记地点、美国癌症联合委员会（AJCC）分期、乳腺亚型、原发肿瘤手术以及非癌症病因手术患者方面存在显著差异。结果还表明，与未进行手术治疗相比，手术治疗，包括原发肿瘤手术、手术联合放疗以及非癌症病因手术，均能有效改善预后。
总之，NECB是一种非常罕见的病变，发现年龄、婚姻状况、登记地点和手术、AJCC分期、乳腺亚型是其独立的预后因素。
