Icahn School of Medicine at Mount Sinai Hospital (Elmhurst Hospital Center), New York, NY, USA.
J Investig Med High Impact Case Rep. 2022 Jan-Dec;10:23247096221121392. doi: 10.1177/23247096221121392.
Sarcomatoid tumors are very rare biphasic tumors characterized by a mixture of malignant epithelial and mesenchymal cells that have been usually identified in the lungs with other documented cases in skin, bone, thyroid gland, salivary glands, breast, and genitourinary and gastrointestinal systems. They have an incidence estimated to be 0.5 to 0.8 per 100 000 per year. Three classic features include the presence of a genuine sarcomatous component, no transitional zone between carcinomatous and sarcomatous components, and immunohistochemistry of the sarcomatous component that is positive for mesenchymal markers and negative for epithelial markers. Sarcomatoid carcinoma of the gastrointestinal tract is rare but more commonly found within the stomach, gallbladder, and esophagus. Small bowel involvement is very rare.
肉瘤样肿瘤是非常罕见的双相性肿瘤，其特征是恶性上皮细胞和间叶细胞的混合，通常在肺部发现，其他有记录的病例见于皮肤、骨骼、甲状腺、唾液腺、乳腺以及泌尿生殖和胃肠道系统。其发病率估计为每年每 10 万人中有 0.5 至 0.8 例。三个典型特征包括存在真正的肉瘤成分、癌性和肉瘤性成分之间没有过渡区，以及肉瘤成分的免疫组织化学呈间叶标志物阳性和上皮标志物阴性。胃肠道的肉瘤样癌较为罕见，但更常见于胃、胆囊和食管。小肠受累非常罕见。
