Department of Allied Health Sciences, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
Institute of Bone and Joint Research, Kolling Institute of Medical Research, The University of Sydney, Sydney, New South Wales, Australia.
Int J Rheum Dis. 2022 Dec;25(12):1408-1415. doi: 10.1111/1756-185X.14435. Epub 2022 Sep 9.
The objectives of this study are to ascertain the determinants of quality of life (QoL) and hand function among persons with hand osteoarthritis (OA) and to assess the influence of hand function on QoL among persons with OA.
Two hundred and four participants in a clinical trial completed the baseline assessment. Demographic, socioeconomic, QoL (AqoL-4D), hand function (Functional Index for Hand Osteoarthritis, FIHOA), pain assessment, radiographic and clinical characteristics of participants were measured using standard methods. Univariate and multivariate analyses were performed to evaluate potential associations.
We studied 204 participants (76% female, age 65.63 ± 8.13 years, body mass index 28.7 ± 6.5 kg/m ) with hand OA. The mean pain score of the participants on a visual analog scale was 57.8 (SD ±13.6). There was a significant, negative moderate correlation between hand function and QoL scores except for the sense domain score. Global assessment, household income and serious illness were associated with QoL (P < .001) and explained 18% of the variance of the QoL. Pain scale, Patient Global Assessment, Mental Health Score, grip strength and cyst index were associated with hand function score and explained 26% of the variance of hand function.
The results indicate increasing impairment in hand function decreases the QoL of persons with hand OA. Some determinants were significantly associated with hand function and QoL. Determinants related to hand functions may be modifiable. In future, appropriate intervention strategies should be implemented, and further studies should be conducted to identify the effectiveness of those interventions.
本研究旨在确定手部骨关节炎（OA）患者生活质量（QoL）和手部功能的决定因素，并评估手部功能对 OA 患者 QoL 的影响。
204 名参加临床试验的参与者完成了基线评估。使用标准方法测量参与者的人口统计学、社会经济状况、生活质量（AqoL-4D）、手部功能（手部骨关节炎功能指数，FIHOA）、疼痛评估、影像学和临床特征。进行单变量和多变量分析以评估潜在关联。
我们研究了 204 名手部 OA 患者（76%女性，年龄 65.63±8.13 岁，体重指数 28.7±6.5 kg/m ）。参与者的视觉模拟量表平均疼痛评分为 57.8（SD±13.6）。手部功能与 QoL 评分之间存在显著、负中度相关性，但感觉域评分除外。总体评估、家庭收入和严重疾病与 QoL 相关（P<.001），解释了 QoL 变异的 18%。疼痛量表、患者总体评估、心理健康评分、握力和囊肿指数与手部功能评分相关，解释了手部功能变异的 26%。
结果表明，手部功能的逐渐受损会降低手部 OA 患者的 QoL。一些决定因素与手部功能和 QoL 显著相关。与手部功能相关的决定因素可能是可改变的。未来应实施适当的干预策略，并进行进一步研究，以确定这些干预措施的有效性。
