Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Department of Surgery, Duke University School of Medicine, Division of Surgical Oncology, Duke Cancer Institute, Durham, North Carolina, USA.
J Surg Oncol. 2022 Oct;126(5):876-880. doi: 10.1002/jso.27030.
Resulting from 50 years of innovation, operations for pancreatic neoplasms can now be performed safely, albeit with significant but manageable morbidity. Molecular diagnosis has allowed for the identification of multiple distinct histopathologies with variable natural histories. Observation is now a strategy for selected indolent cysts and some neuroendocrine neoplasms. For ductal pancreatic adenocarcinoma, a long-term cure remains elusive and will require more than surgical resection for meaningful progress.
经过 50 年的创新，胰腺肿瘤的手术现在可以安全进行，尽管存在显著但可管理的发病率。分子诊断已经能够识别多种具有不同自然病史的独特组织病理学。对于一些惰性囊肿和神经内分泌肿瘤，现在可以选择观察策略。对于导管腺癌，长期治愈仍然难以实现，需要除手术切除以外的更多手段才能取得有意义的进展。
