College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China.
College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China.
Aquat Toxicol. 2022 Oct;251:106290. doi: 10.1016/j.aquatox.2022.106290. Epub 2022 Sep 5.
It was reported that tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) could inhibit the growth of F0-generation fish. However, multi-generation effects of TDCIPP on survival and growth of fish remain unknown. In this study, the effects of TDCIPP on survival and growth in F1 generation zebrafish were evaluated after two-generation exposure. Results demonstrated that TDCIPP inhibited the survival and growth of F1-generation zebrafish at 96 hpf and 30 dpf. Moreover, compared with the F0 generation, two-generation exposure resulted in a greater accumulation of TDCIPP in F1 generation zebrafish, and strongly down-regulated the expression of genes related to the GH/IGF axis (gh, igf1, igf2b) and HPT axis (tshβ). Taken together, for the first time, this study revealed that exposure to TDCIPP for two generations at environmentally relevant concentrations aggravated the adverse effects on growth and survival in zebrafish.
据报道，磷酸三（1,3-二氯-2-丙基）酯（TDCIPP）可抑制 F0 代鱼类的生长。然而，TDCIPP 对鱼类的多代生存和生长的影响仍不清楚。在这项研究中，在两代暴露后评估了 TDCIPP 对 F1 代斑马鱼存活和生长的影响。结果表明，TDCIPP 在 96 hpf 和 30 dpf 时抑制 F1 代斑马鱼的存活和生长。此外，与 F0 代相比，两代暴露导致 F1 代斑马鱼中 TDCIPP 的积累更多，并强烈下调了与 GH/IGF 轴（gh、igf1、igf2b）和 HPT 轴（tshβ）相关的基因的表达。总之，这项研究首次揭示，以环境相关浓度暴露两代 TDCIPP 会加剧对斑马鱼生长和存活的不良影响。
