Division of Public Health, Infectious Diseases and Occupational Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Division of Pediatric Critical Care Medicine, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA; Division of Pediatric Infectious Diseases, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
J Immunol Methods. 2022 Nov;510:113351. doi: 10.1016/j.jim.2022.113351. Epub 2022 Sep 7.
This article aims to describe the clinical manifestations and management of COVID-19 in patients with primary and secondary B cell deficient states. We describe the epidemiologic and clinical features as well as unique management paradigm including isolation precautions with COVID-19. We then focus upon primary and secondary preventive approaches including vaccination and pre- as well as post-exposure prophylaxis. Further, we elaborate upon the important disease specific risk factors in these patients and the need to conduct prospective clinical trials to develop individualized management strategies in this population.
本文旨在描述原发性和继发性 B 细胞缺陷状态患者的 COVID-19 的临床表现和管理。我们描述了流行病学和临床特征以及独特的管理模式，包括 COVID-19 的隔离预防措施。然后，我们重点介绍了包括疫苗接种和暴露前及暴露后预防在内的原发性和继发性预防方法。此外，我们详细阐述了这些患者的重要疾病特异性风险因素，以及在该人群中开展前瞻性临床试验以制定个体化管理策略的必要性。
