Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Cont Lens Anterior Eye. 2023 Feb;46(1):101755. doi: 10.1016/j.clae.2022.101755. Epub 2022 Sep 7.
To compare axial elongation, relative corneal refractive power (RCRP) distribution within the pupillary diameter, and corneal higher-order aberrations (HOAs) in myopic children wearing orthokeratology (ortho-k) lenses with different back optic zone diameters (BOZD).
Children aged 8-11 years were fitted with 5.0 or 6.2 mm-BOZD ortho-k lenses (groups A and B, respectively). Axial length (AL) and corneal topography were measured at baseline and during the annual visit. RCRP and corneal HOAs were compared between the two groups after one-year treatment. Multivariate linear regression analysis was performed to determine the association between AL elongation and RCRP parameters, corneal HOAs, and other variables between the groups.
After one-year treatment, axial elongation was slower in group A than in group B, with a difference of 0.15 mm. Children in group A showed smaller treatment zone size, smaller 3/4X value (describing the distance from the apex RCRP profile rising to its three-quarter-peak level), greater RCRP sum value within the pupillary area, and higher increases in corneal total HOAs and horizontal coma (Z). AL elongation was significantly correlated with baseline age, baseline spherical equivalent refraction (SER), treatment zone size, and 3/4X value.
Ortho-k lenses designed with smaller BOZD increased myopia control efficacy, induced a steeper distribution of the RCRP profile within the pupillary diameter, and induced greater increases in corneal total HOAs and horizontal coma (Z). Lens-induced RCRP profile within pupillary diameter, rising to its three-quarter-peak level at a smaller distance, may show a better myopia control effect.
比较配戴不同后光学区直径(BOZD)角膜塑形镜(ortho-k)的近视儿童的眼轴伸长量、瞳孔直径内的相对角膜屈光力(RCRP)分布和角膜高阶像差(HOAs)。
8-11 岁儿童分别配戴 5.0mm 或 6.2mm-BOZD ortho-k 镜片(A、B 组)。在基线和每年就诊时测量眼轴长度(AL)和角膜地形图。在一年治疗后比较两组之间的 RCRP 和角膜 HOAs。采用多元线性回归分析确定两组之间 AL 伸长与 RCRP 参数、角膜 HOAs 以及其他变量之间的关系。
一年治疗后,A 组的眼轴伸长速度比 B 组慢,差值为 0.15mm。A 组的治疗区尺寸较小,3/4X 值较小(描述从顶点 RCRP 轮廓上升到其四分之三峰值的距离),瞳孔区 RCRP 总和值较大,角膜总 HOAs 和水平彗差(Z)增加较大。AL 伸长与基线年龄、基线球镜等效屈光度(SER)、治疗区尺寸和 3/4X 值显著相关。
BOZD 设计较小的 ortho-k 镜片增加了近视控制效果,在瞳孔直径内引起 RCRP 分布更陡峭,并引起角膜总 HOAs 和水平彗差(Z)增加更大。在瞳孔直径内升高到四分之三峰值的 lens-induced RCRP 轮廓,在更小的距离处,可能显示出更好的近视控制效果。