Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas. USA.
Semin Diagn Pathol. 2023 Jan;40(1):22-36. doi: 10.1053/j.semdp.2022.07.004. Epub 2022 Jul 29.
Ovarian germ cell tumors are a diverse group of benign and malignant neoplasms that occur in a wide age range, but with a predilection for younger age group. The majority are represented by the frequently encountered mature cystic teratomas. Malignant germ cell tumors are uncommon, and in some cases have a characteristic clinical presentation. However, from a histologic standpoint these tumors can sometimes be challenging to diagnose due to overlapping morphology with epithelial, and in some cases sex cord tumors. In these cases, a panel of immunohistochemical stains often facilitates the correct diagnosis. This review article discusses the clinicopathologic findings and pertinent ancillary studies of both common and uncommon germ cell tumors of the ovary.
卵巢生殖细胞肿瘤是一组发生于广泛年龄段但好发于年轻患者的良、恶性肿瘤。其中大多数为常见的成熟囊性畸胎瘤。恶性生殖细胞肿瘤并不常见，部分病例具有特征性临床表现。然而，从组织学角度来看，由于这些肿瘤的形态与上皮性肿瘤和某些情况下的性索肿瘤存在重叠，因此有时诊断具有一定挑战性。在这些情况下，免疫组织化学染色通常有助于正确诊断。本文讨论了卵巢常见和罕见生殖细胞肿瘤的临床病理特征及相关辅助检查。
