Department of Psychiatry, The Third People's Hospital of Foshan, Foshan, Guangdong, People's Republic of China.
BMC Neurol. 2022 Sep 10;22(1):341. doi: 10.1186/s12883-022-02869-x.
People with sleep problems are more likely to have mental disorders. This study aimed to assess the effect of insomnia on the prognosis of patients with major depressive disorder (MDD).
We divided the patients into three groups according to the Insomnia Severity Index (ISI) scores. In addition, we compared the results of the Hamilton Depression Scale (HAMD) and Symptom Checklist-90 (SCL-90) scores. We evaluated the effect of insomnia at the 2nd, 4th, and 8th-week follow-up on the prognosis of MDD.
Fifty-five patients between 19 and 58 years old, with a diagnosis of MDD via the Structured Clinical Interview for the Diagnostic and Statistical Manual-5 (DSM-5). The ISI scores of the moderate and severe group decreased significantly (P < 0.05) in the 2nd week compared to the baseline. The HAMD scores in all groups improved significantly in the 2nd week.
This study was inspired to assess insomnia as a comorbid disorder for patients with MDD, which may bring poor treatment consequences.
有睡眠问题的人更有可能患有精神障碍。本研究旨在评估失眠对重度抑郁症（MDD）患者预后的影响。
我们根据失眠严重程度指数（ISI）评分将患者分为三组。此外，我们比较了汉密尔顿抑郁量表（HAMD）和症状清单-90（SCL-90）评分的结果。我们评估了失眠在第 2、4 和 8 周随访时对 MDD 预后的影响。
55 名年龄在 19 至 58 岁之间的患者，通过诊断和统计手册-5（DSM-5）的结构临床访谈被诊断为 MDD。中重度组的 ISI 评分在第 2 周与基线相比显著下降（P < 0.05）。所有组的 HAMD 评分在第 2 周均显著改善。
本研究旨在评估失眠作为 MDD 患者的共病障碍，这可能带来不良的治疗后果。
