免疫“冷”型三阴性乳腺癌在患者来源的异种移植模型中具有更高的移植率。
Immunologically "cold" triple negative breast cancers engraft at a higher rate in patient derived xenografts.
作者信息
Petrosyan Varduhi, Dobrolecki Lacey E, LaPlante Emily L, Srinivasan Ramakrishnan Rajaram, Bailey Matthew H, Welm Alana L, Welm Bryan E, Lewis Michael T, Milosavljevic Aleksandar
机构信息
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA.
出版信息
NPJ Breast Cancer. 2022 Sep 10;8(1):104. doi: 10.1038/s41523-022-00476-0.
TNBC is a heterogeneous subtype of breast cancer, and only a subset of TNBC can be established as PDXs. Here, we show that there is an engraftment bias toward TNBC with low levels of immune cell infiltration. Additionally, TNBC that failed to engraft show gene expression consistent with a cancer-promoting immunological state, leading us to hypothesize that the immunological state of the tumor and possibly the state of the immune system of the host may be essential for engraftment.
三阴性乳腺癌（TNBC）是乳腺癌的一种异质性亚型，只有一部分TNBC能够被建立为移植瘤模型（PDXs）。在此，我们表明，对于免疫细胞浸润水平低的TNBC存在植入偏向性。此外，未能成功植入的TNBC表现出与促癌免疫状态一致的基因表达，这使我们推测肿瘤的免疫状态以及宿主免疫系统的状态可能对植入至关重要。
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