Karele Emija Nikola, Paze Anda Nikola
Faculty of Medicine, Riga Stradins University, 16 Dzirciema Street, Riga LV-1007, Latvia.
Biochim Biophys Acta Rev Cancer. 2022 Sep;1877(5):188796. doi: 10.1016/j.bbcan.2022.188796. Epub 2022 Sep 9.
Chordoma is a rare type of bone cancer characterized by its locally aggressive and destructive behavior. Chordoma is located in one of the three primary regions: skull base/clivus, sacrum or mobile spine. Chordoma grows slowly, therefore its insidious onset leads to delayed diagnosis, accounting for the low survival rates. Treatment centers around successful en bloc resection with negative margins, though, considering the anatomically constrained site of growth, it frequently requires adjuvant radiotherapy. This article analyzes the existing literature with the aim to provide a better insight in the current state of research in chordoma classification, characteristics, and management.
脊索瘤是一种罕见的骨癌，其特点是具有局部侵袭性和破坏性。脊索瘤位于三个主要部位之一：颅底/斜坡、骶骨或活动脊柱。脊索瘤生长缓慢，因此其隐匿性起病导致诊断延迟，这也是生存率较低的原因。治疗的核心是成功进行切缘阴性的整块切除，不过，鉴于其生长部位在解剖结构上受限，通常还需要辅助放疗。本文分析现有文献，旨在更好地洞察脊索瘤分类、特征及治疗的当前研究状况。
