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中国罕见癌症研究中的挑战与机遇。

Challenges and opportunities in rare cancer research in China.

机构信息

Division of Thoracic Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, China.

National Natural Science Foundation of China, Beijing, 100085, China.

出版信息

Sci China Life Sci. 2024 Feb;67(2):274-285. doi: 10.1007/s11427-023-2422-x. Epub 2023 Nov 23.

DOI:10.1007/s11427-023-2422-x
PMID:38036799
Abstract

Cancer is one of the major public health challenges in China. Rare cancers collectively account for a considerable proportion of all malignancies. The lack of awareness of rare cancers among healthcare professionals and the general public, the typically complex and delayed diagnosis, and limited access to clinical trials are key challenges. Recent years have witnessed an increase in funding for research related to rare cancers in China. In this review, we provide a comprehensive overview of rare cancers and summarize the status of research on rare cancers in China and overseas, including the trends of funding and publications. We also highlight the challenges and perspectives regarding rare cancers in China.

摘要

癌症是中国面临的主要公共卫生挑战之一。罕见癌症在所有恶性肿瘤中占有相当大的比例。医疗专业人员和公众对罕见癌症的认识不足、典型的复杂和延迟诊断以及临床试验的有限机会是主要挑战。近年来,中国对罕见癌症相关研究的资金投入有所增加。在这篇综述中,我们全面概述了罕见癌症,并总结了国内外罕见癌症研究的现状,包括资金和出版物的趋势。我们还强调了中国罕见癌症面临的挑战和前景。

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3
Immunotherapies in rare cancers.罕见癌症的免疫疗法。
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Sci China Life Sci. 2024 Sep;67(9):1928-1940. doi: 10.1007/s11427-023-2523-5. Epub 2024 May 23.
Mol Cancer. 2023 Feb 1;22(1):23. doi: 10.1186/s12943-023-01720-2.
4
Clinical characteristics and outcomes of gastrointestinal stromal tumor patients receiving surgery with or without TKI therapy: a retrospective real-world study.接受手术联合或不联合 TKI 治疗的胃肠道间质瘤患者的临床特征和结局:一项回顾性真实世界研究。
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5
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