Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710049, China.
State Key Laboratory for Mechanical Behavior of Materials, and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
ACS Appl Mater Interfaces. 2022 Sep 21;14(37):41726-41741. doi: 10.1021/acsami.2c10490. Epub 2022 Sep 11.
The on-demand replacement of multifunctional hydrogel wound dressings helps to avoid bacterial colonization, and the on-demand painless peeling of tissue adhesive hydrogels on the wound site remains a major challenge to be solved. In this work, we design and develop a series of multifunctional dynamic Schiff base network hydrogels composed of cystamine-modified hyaluronic acid, benzaldehyde-functionalized poly(ethylene glycol)-co-poly(glycerol sebacate), and polydopamine@polypyrrole nanocomposite (PDA@PPy) with mild on-demand removability to enhance drug-resistant bacteria-infected wound healing. These hydrogels exhibited ideal injectable and self-healing properties, excellent tissue adhesion, in vivo hemostasis, good antioxidation, and conductivity. PDA@PPy inspired by melanin endows hydrogels with excellent antioxidant capacity, UV-blocking ability, and photothermal anti-infection ability. Based on the dynamic oxidation-reduction response of disulfide bonds inspired by the dissociation of the tertiary spatial structure transformation of poly-polypeptide chains, these hydrogels can achieve rapid painless on-demand removal under mild conditions by adding dithiothreitol. These multifunctional hydrogels significantly promoted collagen deposition and angiogenesis in the MRSA-infected full-thickness skin repair experiment. All the results showed that these multifunctional hydrogels with painless on-demand removal property showed great potential in clinical treatment of infected wounds.
按需替换多功能水凝胶伤口敷料有助于避免细菌定植，而在伤口部位按需无痛剥离组织胶粘剂水凝胶仍然是一个需要解决的主要挑战。在这项工作中，我们设计和开发了一系列多功能动态席夫碱网络水凝胶，由半胱胺修饰的透明质酸、苯甲醛功能化的聚（乙二醇）-共-聚（甘油癸二酸酯）和聚多巴胺@聚吡咯纳米复合材料（PDA@PPy）组成，具有温和的按需去除性，以增强耐抗生素细菌感染伤口的愈合。这些水凝胶表现出理想的可注射性和自修复性能、优异的组织粘附性、体内止血、良好的抗氧化性和导电性。受黑色素启发的 PDA@PPy 赋予水凝胶优异的抗氧化能力、紫外线阻挡能力和光热抗感染能力。基于多肽链三级空间结构转变解离所启发的二硫键的动态氧化还原响应，通过添加二硫苏糖醇，这些水凝胶可以在温和条件下快速无痛按需去除。这些多功能水凝胶在 MRSA 感染的全厚皮肤修复实验中显著促进了胶原蛋白沉积和血管生成。所有结果表明，这些具有无痛按需去除性能的多功能水凝胶在感染性伤口的临床治疗中具有巨大的潜力。
