Alomar Abdullah A, Eastmond Bradley H, Rapti Zoi, Walker Edward D, Alto Barry W
Florida Medical Entomology Laboratory, University of Florida, Vero Beach, FL, United States.
Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Front Microbiol. 2022 Aug 26;13:933482. doi: 10.3389/fmicb.2022.933482. eCollection 2022.
Dengue virus (DENV) is a highly prevalent vector-borne virus that causes life-threatening illnesses to humans worldwide. The development of a tool to control vector populations has the potential to reduce the burden of DENV. Toxic sugar bait (TSB) provides a form of vector control that takes advantage of the sugar-feeding behavior of adult mosquitoes. However, studies on the effect of ingestion of toxins in TSB on vector competence and vectorial capacity for viruses are lacking. This study evaluated vector competence for DENV serotype-1 of at 7 and 14 days post-ingestion of TSB formulated with spinosad (of bacteria origin) as an oral toxin. Our results and others were modeled to estimate effects on vectorial capacity for DENV. Ingestion of TSB caused a reduction in survival of females, but increased mosquito susceptibility to DENV infection, disseminated infection, and transmission. However, this increase in vector competence was obviated by the reduction in survival, leading to a lower predicted vectorial capacity. The findings of this study highlight the importance of evaluating the net impact of TSB ingestion on epidemiological parameters of vectorial capacity in the context of vector control efforts to reduce the risk of transmission of vector-borne viruses.
登革病毒（DENV）是一种高度流行的媒介传播病毒，可在全球范围内引发危及人类生命的疾病。开发一种控制媒介种群的工具有可能减轻登革病毒的负担。毒糖诱饵（TSB）提供了一种利用成年蚊子取食糖分行为的媒介控制形式。然而，关于摄入TSB中的毒素对病毒的媒介能力和传播能力的影响的研究尚属空白。本研究评估了以多杀菌素（来源于细菌）作为口服毒素配制的TSB摄入后7天和14天，埃及伊蚊对登革病毒1型的媒介能力。我们的研究结果以及其他研究结果被建模以估计对登革病毒传播能力的影响。摄入TSB导致雌蚊存活率降低，但增加了蚊子对登革病毒感染、播散性感染和传播的易感性。然而，存活率的降低消除了这种媒介能力的增加，导致预测的传播能力降低。本研究结果强调了在控制媒介以降低媒介传播病毒传播风险的背景下，评估摄入TSB对传播能力流行病学参数的净影响的重要性。
