Njoroge Teresia Muthoni, Hamid-Adiamoh Majidah, Duman-Scheel Molly
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Raclin-Carmichael Hall, 1234 Notre Dame Ave., South Bend, IN 46617, USA.
Eck Institute for Global Health, The University of Notre Dame, Notre Dame, South Bend, IN 46556, USA.
Insects. 2023 Jun 28;14(7):585. doi: 10.3390/insects14070585.
Due to the limitations of the human therapeutics and vaccines available to treat and prevent mosquito-borne diseases, the primary strategy for disease mitigation is through vector control. However, the current tools and approaches used for mosquito control have proven insufficient to prevent malaria and arboviral infections, such as dengue, Zika, and lymphatic filariasis, and hence, these diseases remain a global public health threat. The proven ability of mosquito vectors to adapt to various control strategies through insecticide resistance, invasive potential, and behavioral changes from indoor to outdoor biting, combined with human failures to comply with vector control requirements, challenge sustained malaria and arboviral disease control worldwide. To address these concerns, increased efforts to explore more varied and integrated control strategies have emerged. These include approaches that involve the behavioral management of vectors. Attractive targeted sugar baits (ATSBs) are a vector control approach that manipulates and exploits mosquito sugar-feeding behavior to deploy insecticides. Although traditional approaches have been effective in controlling malaria vectors indoors, preventing mosquito bites outdoors and around human dwellings is challenging. ATSBs, which can be used to curb outdoor biting mosquitoes, have the potential to reduce mosquito densities and clinical malaria incidence when used in conjunction with existing vector control strategies. This review examines the available literature regarding the utility of ATSBs for mosquito control, providing an overview of ATSB active ingredients (toxicants), attractants, modes of deployment, target organisms, and the potential for integrating ATSBs with existing vector control interventions.
由于用于治疗和预防蚊媒疾病的人类治疗方法和疫苗存在局限性，减轻疾病的主要策略是通过病媒控制。然而，目前用于控制蚊子的工具和方法已被证明不足以预防疟疾和虫媒病毒感染，如登革热、寨卡病毒和淋巴丝虫病，因此，这些疾病仍然是全球公共卫生威胁。蚊媒通过抗药性、入侵潜力以及从室内叮咬到室外叮咬的行为变化来适应各种控制策略的能力，再加上人类未能遵守病媒控制要求，对全球持续控制疟疾和虫媒病毒病构成了挑战。为了解决这些问题，人们加大了探索更多样化和综合控制策略的力度。这些策略包括涉及病媒行为管理的方法。有吸引力的靶向糖饵（ATSBs）是一种病媒控制方法，它操纵并利用蚊子的取食行为来施用杀虫剂。虽然传统方法在室内控制疟疾媒介方面很有效，但在户外和人类住所周围防止蚊子叮咬具有挑战性。可用于抑制室外叮咬蚊子的ATSBs，与现有的病媒控制策略结合使用时，有可能降低蚊子密度和临床疟疾发病率。这篇综述研究了关于ATSBs用于蚊子控制的现有文献，概述了ATSBs的活性成分（毒物）、引诱剂、部署方式、目标生物，以及将ATSBs与现有病媒控制干预措施相结合的潜力。
