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前蛋白转化酶枯草溶菌素/克尔新9型（PCSK9）在银屑病和系统性红斑狼疮病理生理学中的作用。

The role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in the pathophysiology of psoriasis and systemic lupus erythematosus.

作者信息

Frątczak Aleksandra, Polak Karina, Szczepanek Michał, Lis-Święty Anna

机构信息

Department of Dermatology, Medical University of Silesia, Katowice, Poland.

出版信息

Postepy Dermatol Alergol. 2022 Aug;39(4):645-650. doi: 10.5114/ada.2022.118919. Epub 2022 Sep 1.

DOI:10.5114/ada.2022.118919
PMID:36090718
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9454343/
Abstract

Inflammation and atherogenic dyslipidaemia are often observed in skin diseases and represent an increased risk of cardiovascular disorders. Proprotein convertase subtilisin/kexin type 9 plays an important role in the regulation of serum low-density lipoprotein cholesterol levels. Its biological role, however, seems to go much beyond the regulation of cholesterol metabolism. The article presents potential pathophysiological links between inflammatory process and lipid disorders based on the example of psoriasis and systemic lupus erythematosus.

摘要

炎症和致动脉粥样硬化血脂异常在皮肤病中经常出现，代表着心血管疾病风险的增加。前蛋白转化酶枯草溶菌素/克新9型在血清低密度脂蛋白胆固醇水平的调节中起重要作用。然而，其生物学作用似乎远远超出了胆固醇代谢的调节。本文以银屑病和系统性红斑狼疮为例，阐述了炎症过程与脂质紊乱之间潜在的病理生理联系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf9e/9454343/9063e0f3b98d/PDIA-39-47672-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf9e/9454343/70abc7c8b762/PDIA-39-47672-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf9e/9454343/9063e0f3b98d/PDIA-39-47672-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf9e/9454343/70abc7c8b762/PDIA-39-47672-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf9e/9454343/9063e0f3b98d/PDIA-39-47672-g002.jpg

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J Invest Dermatol. 2021 Feb;141(2):308-315. doi: 10.1016/j.jid.2020.05.115. Epub 2020 Jun 29.
2
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Lupus. 2020 Jul;29(8):825-835. doi: 10.1177/0961203320926253. Epub 2020 Jun 1.
3
Methotrexate Decreases the Level of PCSK9-A Novel Indicator of the Risk of Proatherogenic Lipid Profile in Psoriasis. The Preliminary Data.
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Life (Basel). 2023 Sep 6;13(9):1873. doi: 10.3390/life13091873.
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Crosstalk between cholesterol metabolism and psoriatic inflammation.胆固醇代谢与银屑病炎症之间的串扰。
Front Immunol. 2023 May 10;14:1124786. doi: 10.3389/fimmu.2023.1124786. eCollection 2023.
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Considerations of the Genetic Background of Obesity among Patients with Psoriasis.考虑银屑病患者肥胖的遗传背景。
Genes (Basel). 2023 Feb 26;14(3):594. doi: 10.3390/genes14030594.
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