Itoh Shinji, Tomiyama Takahiro, Morinaga Akinari, Kurihara Takeshi, Nagao Yoshihiro, Toshima Takeo, Morita Kazutoyo, Harada Noboru, Mori Masaki, Yoshizumi Tomoharu
Department of Surgery and Science, Graduate School of Medical Sciences Kyushu University Fukuoka Japan.
Tokai University School of Medicine Isehara Japan.
Ann Gastroenterol Surg. 2022 Mar 9;6(5):688-694. doi: 10.1002/ags3.12563. eCollection 2022 Sep.
This study aimed to clarify the clinical effects of the indocyanine green (ICG)-fluorescence imaging (FI) technique for determination of liver transection lines during laparoscopic partial liver resection for liver tumors.
This was a retrospective study including 112 patients who underwent laparoscopic partial liver resection for liver tumors. These enrolled patients were divided into an ICG-FI group (n = 55) and a non-ICG-FI group (n = 57) according to the availability of the ICG-FI. The clinicopathological characteristics of patients between two groups were compared before and after propensity score matching.
The ICG-FI and non-ICG-FI groups differed at baseline in terms of ICG retention rate at 15 min. After propensity score matching, two comparable groups of 32 patients each were obtained. The negativity rated of the pathological surgical margins were comparable between the two groups before and after propensity score matching. However, the surgical margins were significantly wider in the ICG-FI group before and after propensity score matching ( = .039 and = .047, respectively).
The ICG-fluorescence imaging technique may offer clinical benefits in terms of a secure surgical margin in laparoscopic partial liver resection.
本研究旨在阐明吲哚菁绿（ICG）荧光成像（FI）技术在腹腔镜肝肿瘤部分肝切除术中确定肝切线的临床效果。
这是一项回顾性研究，纳入了112例行腹腔镜肝肿瘤部分肝切除术的患者。根据是否采用ICG-FI，将这些入选患者分为ICG-FI组（n = 55）和非ICG-FI组（n = 57）。在倾向评分匹配前后比较两组患者的临床病理特征。
ICG-FI组和非ICG-FI组在基线时15分钟ICG滞留率方面存在差异。经过倾向评分匹配后，得到了两组各32例可比的患者。倾向评分匹配前后两组的病理手术切缘阴性率相当。然而，倾向评分匹配前后ICG-FI组的手术切缘明显更宽（分别为P = 0.039和P = 0.047）。
ICG荧光成像技术在腹腔镜部分肝切除术中确保手术切缘方面可能具有临床益处。
