Department of Health Management, Aerospace Center Hospital, Beijing, China.
Front Public Health. 2022 Aug 26;10:966847. doi: 10.3389/fpubh.2022.966847. eCollection 2022.
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with mutations in the spike protein has risen concerns about the efficacy of infection- or vaccine-induced antibodies and has posed a serious threat to global public health, education, travel and economy. Few studies have described the detailed characterizations of highly cited articles on SARS-CoV-2 variants.
To identify and characterize the 100 most-cited articles in SARS-CoV-2 variants research.
Articles published recently were extracted from the web of science core collection database using a query based on MeSH terms and topics of SARS-CoV-2 and variants. Characteristics of the 100 most-cited articles were analyzed the following parameters: publication number over year, number of citations, type of articles, authors, journal, journal impact factor, country, and topics covered in articles. In addition, clinical trials in these articles were also analyzed.
The majority of articles (66%) were published in 2021. Number of citations of the 100 most cited articles ranged from 1720 to 75 (median: 178.5). Mutations in the S protein such as D614G mutation and the B.1.1.7 (UK) and B.1.351 (South Africa) were the dominant variants in the 100 most cited articles. The United States, the United Kingdom, and South Africa had the strongest collaboration in the contribution of publication. Science, Cell, Nature and New England Journal of Medicine were mostly cited and the main direction in these top journals were vaccine neutralizing tests and efficacy evaluation studies. Response of antibody neutralization tests against variants was always weakened due to the presence of variants but the results of clinical trials were encouraging. Genomics information, spike protein structure confirmation and neutralization studies evaluating antibody resistance were highly represented in the 100 most cited articles in SARS-CoV-2 variants literature.
Altogether, genomic information, epidemiology, immune neutralization, and vaccine efficacy studies of COVID-19 variants are the main research orientations in these articles and relevant results have been published in influential journals. Given the continuous evolution of the SARS-CoV-2 and the constant development in our understanding of the impact of variants, current working strategies and measures may be periodically adjusted.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）变体的出现，其刺突蛋白发生突变，这引发了人们对感染或疫苗诱导的抗体有效性的担忧，并对全球公共卫生、教育、旅行和经济构成了严重威胁。很少有研究描述过 SARS-CoV-2 变体高引文章的详细特征。
确定和描述 SARS-CoV-2 变体研究中被引次数最多的 100 篇文章。
使用基于 SARS-CoV-2 和变体的 MeSH 术语和主题的查询，从 web of science 核心合集数据库中提取最近发表的文章。分析了 100 篇被引次数最多的文章的特征，包括每年发表的文章数量、被引次数、文章类型、作者、期刊、期刊影响因子、国家以及文章涵盖的主题。此外，还分析了这些文章中的临床试验。
大多数文章（66%）发表于 2021 年。100 篇被引次数最多的文章的被引次数范围为 1720 次至 75 次（中位数：178.5 次）。S 蛋白中的突变，如 D614G 突变以及 B.1.1.7（英国）和 B.1.351（南非）变体，是在 100 篇被引次数最多的文章中占主导地位的变体。美国、英国和南非在发表论文的合作方面最为紧密。Science、Cell、Nature 和 New England Journal of Medicine 的被引次数最多，这些期刊的主要方向是疫苗中和试验和疗效评估研究。由于变体的存在，抗体中和试验对变体的反应总是减弱，但临床试验的结果令人鼓舞。SARS-CoV-2 变体文献中，对基因组信息、刺突蛋白结构确认以及评估抗体耐药性的中和研究高度重视。
总的来说，COVID-19 变体的基因组信息、流行病学、免疫中和和疫苗效力研究是这些文章的主要研究方向，相关结果已发表在有影响力的期刊上。鉴于 SARS-CoV-2 的持续进化以及我们对变体影响的不断认识，当前的工作策略和措施可能会定期进行调整。
