Cain D P
Exp Neurol. 1987 Aug;97(2):243-54. doi: 10.1016/0014-4886(87)90086-0.
Picrotoxin kindling was examined in hooded rats by intraperitoneal or intracerebral injection in different groups. Repeated intraperitoneal injection resulted in the progressive kindling of convulsions in a dose-related manner. Bidirectional transfer to electrical kindling of the amygdala was also observed. Intraamygdala injection of small doses through a chemitrode resulted in progressive kindling and subsequent transfer to electrical kindling. Intraamygdala injection of large doses generally resulted in status epilepticus and the subsequent inability to evoke afterdischarge during transfer testing due to considerable tissue damage surrounding the chemitrode tip. Picrotoxin kindling is similar to kindling by a variety of convulsant agents. However, direct injection into the amygdala easily evokes status epilepticus and brain damage.
在不同组的有帽大鼠中，通过腹腔内或脑内注射来研究印防己毒素点燃效应。反复腹腔内注射会以剂量相关的方式导致惊厥的渐进性点燃。还观察到向杏仁核电点燃的双向转变。通过化学电极向杏仁核内注射小剂量会导致渐进性点燃并随后转变为电点燃。向杏仁核内注射大剂量通常会导致癫痫持续状态，并且在转移测试期间由于化学电极尖端周围相当大的组织损伤而随后无法诱发放电后电位。印防己毒素点燃效应与多种惊厥剂引起的点燃效应相似。然而，直接注射到杏仁核中很容易诱发癫痫持续状态和脑损伤。
