生活方式与循环 FGF21 水平之间的密切关联：系统评价和荟萃分析。
Close association between lifestyle and circulating FGF21 levels: A systematic review and meta-analysis.
机构信息
Institute of Gerontology, Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Gerontology Center of Hubei Province, Wuhan, China.
出版信息
Front Endocrinol (Lausanne). 2022 Aug 25;13:984828. doi: 10.3389/fendo.2022.984828. eCollection 2022.
BACKGROUND
The impact of lifestyle factors on circulating fibroblast growth factor 21 (cFGF21) remains unclear. We conducted this systematic review and meta-analysis to evaluate the association between lifestyle factors and cFGF21 levels.
METHODS
We included studies that evaluated the effects of different lifestyles on cFGF21 concentration in adults, which included smoking, exercise, diets, alcohol consumption and weight loss. Random effects models or fixed effects models were used for meta-analysis to calculate the standardized mean difference (SMD) and 95% confidence interval according to the heterogeneity among studies. Study quality was assessed using the Newcastle-Ottawa Scale for cohort studies, the Joanna Briggs Institution Checklist for cross-sectional studies, and the PEDro scale for experimental studies.
RESULTS
A total of 50 studies with 1438 individuals were included. Overall, smoking, a hypercaloric carbohydrate-rich diet, a hypercaloric fat-rich diet, amino acid or protein restriction, excessive fructose intake and alcohol consumption significantly upregulated cFGF21 levels (p<0.05), whereas fish oil intake and calorie restriction with sufficient protein intake significantly decreased cFGF21 (p<0.05). Compared to the preexercise cFGF21 level, the cFGF21 level significantly increased within 3 hours postexercise (p<0.0001), while it significantly decreased in the blood sampled >6 h postexercise (p=0.01). Moreover, higher exercise intensity resulted in higher upregulation of cFGF21 at 1-hour post exercise (p=0.0006).
CONCLUSION
FGF21 could serve as a potential biomarker for the assessment of different lifestyle interventions. When it is used for this purpose, a standard study protocol needs to be established, especially taking into consideration the intervention types and the sampling time post-intervention.
SYSTEMATIC REVIEW REGISTRATION
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021254758, identifier CRD42021254758.
背景
生活方式因素对循环成纤维细胞生长因子 21（cFGF21）的影响尚不清楚。我们进行了这项系统评价和荟萃分析，以评估生活方式因素与 cFGF21 水平之间的关系。
方法
我们纳入了评估不同生活方式对成年人 cFGF21 浓度影响的研究，这些生活方式包括吸烟、运动、饮食、饮酒和减肥。根据研究之间的异质性，使用随机效应模型或固定效应模型进行荟萃分析，计算标准化均数差（SMD）和 95%置信区间。使用纽卡斯尔-渥太华量表（Newcastle-Ottawa Scale）评估队列研究的质量，使用 Joanna Briggs 机构清单（Joanna Briggs Institution Checklist）评估横断面研究的质量，使用 PEDro 量表（PEDro scale）评估实验研究的质量。
结果
共纳入 50 项研究，共 1438 人。总体而言，吸烟、高卡路里碳水化合物丰富的饮食、高卡路里脂肪丰富的饮食、氨基酸或蛋白质限制、过量果糖摄入和饮酒显著上调 cFGF21 水平（p<0.05），而鱼油摄入和热量限制加足够的蛋白质摄入显著降低 cFGF21（p<0.05）。与运动前的 cFGF21 水平相比，运动后 3 小时内 cFGF21 水平显著升高（p<0.0001），而运动后 6 小时以上采血时 cFGF21 水平显著降低（p=0.01）。此外，更高的运动强度导致运动后 1 小时 cFGF21 的上调更高（p=0.0006）。
结论
FGF21 可以作为评估不同生活方式干预的潜在生物标志物。当将其用于此目的时，需要建立一个标准的研究方案，特别是要考虑干预类型和干预后采样时间。
系统评价注册
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021254758，标识符 CRD42021254758。
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