Alberta Precision Laboratories, Alberta, Canada.
Department of Pathology and Laboratory Medicine, University of Alberta, Edmonton, Alberta, Canada.
Expert Rev Mol Diagn. 2022 Aug;22(8):797-809. doi: 10.1080/14737159.2022.2122712. Epub 2022 Sep 14.
Detection of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has been critical to support and management of the COVID-19 pandemic. Point of care testing (POCT) for SARS-CoV-2 has been a widely used tool for detection of SARS-CoV-2.
POCT nucleic acid amplification tests (NAATs) and rapid antigen tests (RATs) have been the most readily used POCT for SARS-CoV-2. Here, current knowledge on the utility of POCT NAATs and RATs for SARS-CoV-2 are reviewed and discussed alongside aspects of quality assurance factors that must be considered for successful and safe implementation of POCT.
Use cases for implementation of POCT must be evidence based, regardless of the test used. A quality assurance framework must be in place to ensure accuracy and safety of POCT.
检测严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)对于支持和管理 COVID-19 大流行至关重要。即时检测(POCT)已成为检测 SARS-CoV-2 的广泛应用工具。
POCT 核酸扩增检测(NAAT)和快速抗原检测(RAT)是最常用于 SARS-CoV-2 的 POCT。在这里,审查并讨论了 POCT NAAT 和 RAT 对 SARS-CoV-2 的效用,以及为成功和安全实施 POCT 必须考虑的质量保证因素。
无论使用哪种检测方法,POCT 的实施用例都必须基于证据。必须建立质量保证框架,以确保 POCT 的准确性和安全性。