即时检测 SARS-CoV-2。

Detection of SARS-CoV-2 at the point of care.

机构信息

Cepheid, Sunnyvale, CA, USA.

Danaher Diagnostic Platform, Shanghai, China.

出版信息

Bioanalysis. 2021 Aug;13(15):1213-1223. doi: 10.4155/bio-2021-0078. Epub 2021 Jul 22.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of COVID-19. Testing for SARS-CoV-2 infection is a critical element of the public health response to COVID-19. Point-of-care (POC) tests can drive patient management decisions for infectious diseases, including COVID-19. POC tests are available for the diagnosis of SARS-CoV-2 infections and include those that detect SARS-CoV-2 antigens as well as amplified RNA sequences. We provide a review of SARS-CoV-2 POC tests including their performance, settings for which they might be used, their impact and future directions. Further optimization and validation, new technologies as well as studies to determine clinical and epidemiological impact of SARS-CoV-2 POC tests are needed.

摘要

严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)是 COVID-19 的病原体。SARS-CoV-2 感染的检测是 COVID-19 公共卫生应对的关键要素。即时检测(POC)可用于传染病的患者管理决策,包括 COVID-19。POC 检测可用于 SARS-CoV-2 感染的诊断,包括检测 SARS-CoV-2 抗原和扩增 RNA 序列的检测。我们对 SARS-CoV-2 POC 检测进行了综述,包括它们的性能、可能使用的场景、它们的影响和未来方向。需要进一步优化和验证、新技术以及研究来确定 SARS-CoV-2 POC 检测的临床和流行病学影响。

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