Alcohol Research Group, Public Health Institute, Emeryville, California.
The Scripps Research Institute, La Jolla, California.
J Ethn Subst Abuse. 2024 Jul-Sep;23(3):450-470. doi: 10.1080/15332640.2022.2111388. Epub 2022 Sep 10.
We investigated the substance-specific and cross-substance risk associated with early onset (before age 15) of drunkenness and cannabis use in the subsequent development of alcohol (AUD) and cannabis use disorder (CUD) in Mexican American young adults. Survival analyses employed Cox proportional hazards models for AUD and CUD, separately. In cross-risk analyses, we modeled estimates for those participants reporting lifetime use of substances. Early onset of drunkenness and early onset of cannabis use were associated with shorter time to AUD and CUD, respectively, even after accounting for psychiatric disorders. While there were no cross-risk associations, adjusting for psychiatric disorders and early onset cannabis use attenuated the association of early drunkenness with AUD.
我们研究了墨西哥裔美国青年中,早期(15 岁之前)醉酒和大麻使用与随后酒精(AUD)和大麻使用障碍(CUD)发展之间的物质特异性和跨物质风险。生存分析分别采用 Cox 比例风险模型进行 AUD 和 CUD 分析。在跨风险分析中,我们对报告有终生使用物质的参与者进行了模型估计。即使考虑到精神障碍,醉酒和大麻使用的早期发作也与 AUD 和 CUD 的发病时间更短有关。虽然没有跨风险关联,但调整精神障碍和早期大麻使用会减弱早期醉酒与 AUD 之间的关联。