Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA.
Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA.
Drug Alcohol Depend. 2019 Sep 1;202:76-86. doi: 10.1016/j.drugalcdep.2019.06.001. Epub 2019 Jul 6.
Electrophysiological variables may represent sensitive biomarkers of vulnerability to or endophenotypes for alcohol use disorders (AUD).
Young adults (age 18-30 yrs, n = 580) of Mexican American heritage were assessed with the Semi-Structured Assessment for the Genetics of Alcoholism and event-related oscillations (EROs) generated in response to a task that used pictures of objects, food, and alcohol-related and non-alcohol-related drinks as stimuli.
Decreases in energy in the alpha and beta frequencies and higher phase synchrony within cortical brain areas were seen in response to the alcohol-related as compared to the non-alcohol-related stimuli. Differences in ERO energy and synchrony responses to alcohol-related stimuli were also found as a function of age, sex, AUD status and comorbidity. Age-related decreases in energy and increases in synchrony were found. Females had significantly higher energy and lower synchrony values than males. Participants with AUD had higher synchrony values specifically in the beta frequencies, whereas those with a lifetime diagnosis of conduct disorder and/or antisocial personality disorder had lower alpha power and synchrony, and those with any affective disorder had lower ERO energy in the beta frequencies. Those with substance-associated affective "dark-side" symptoms had slower reaction times to the task, lower energy in the beta frequencies, lower local synchrony in the theta frequencies, and higher long-range synchrony in the delta and beta frequencies.
These findings suggest that EROs recorded to alcohol-related stimuli may be biomarkers of comorbid risk factors, symptoms and disorders associated with AUD that also can differentiate those with "dark-side symptoms".
电生理变量可能代表对酒精使用障碍（AUD）易感性或表型的敏感生物标志物。
评估了具有墨西哥裔美国人血统的年轻成年人（年龄 18-30 岁，n=580），他们接受了酒精遗传学半结构化评估和与事件相关的振荡（EROs）的评估，该任务使用物体、食物以及与酒精相关和非酒精相关饮料的图片作为刺激。
与非酒精相关刺激相比，对酒精相关刺激的反应中，α 和β 频率的能量降低，皮质脑区的相位同步性更高。对酒精相关刺激的 ERO 能量和同步反应也发现了差异，其与年龄、性别、AUD 状态和合并症有关。发现与年龄相关的能量降低和同步性增加。女性的能量值明显高于男性，同步值明显低于男性。AUD 患者的同步值明显更高，特别是在β 频率，而患有终身品行障碍和/或反社会人格障碍的患者的α 功率和同步性较低，患有任何情感障碍的患者β 频率的 ERO 能量较低。那些有物质相关情感“黑暗面”症状的患者对任务的反应时间较慢，β 频率的能量较低，θ 频率的局部同步性较低，δ 和β 频率的长程同步性较高。
这些发现表明，对酒精相关刺激记录的 ERO 可能是 AUD 相关共病风险因素、症状和障碍的生物标志物，也可以区分那些有“黑暗面症状”的患者。
