Department of Psychology, Colorado State University, Fort Collins, Colorado, USA.
Cannabis Cannabinoid Res. 2024 Jun;9(3):e917-e923. doi: 10.1089/can.2022.0293. Epub 2023 Sep 12.
College student cannabis use has increased significantly in recent years, and individuals aged 18-25 are at elevated risk for development of cannabis use disorder (CUD). While weekly cannabis use frequency is a commonly used measure of cannabis consumption, there is increasing scientific interest in exploring more nuanced measures of cannabis use. Currently, limited research exists examining the clinical utility of cannabis quantity, within-day frequency, and potency variables. We used cross-sectional survey data from a sample of 617 undergraduate students in the state of Colorado. A two-part model-building approach was leveraged to examine whether within-session cannabis quantity and within-day cannabis use frequency were associated with odds of experiencing any CUD symptoms and total number of CUD symptoms endorsed. We also examined whether cannabis flower potency was associated with odds of experiencing any CUD symptoms and total number of CUD symptoms endorsed among a subset (=288) of the sample who reported knowledge of the cannabinoid content of their most frequently used products. Weekly flower use frequency (odds ratio [OR]=1.27, <0.001) and weekly concentrate use frequency (OR=1.10, =0.044) were positively associated with increased odds of experiencing any CUD symptoms, but cannabis quantity and within-day frequency variables were not. In addition, no association was found between flower potency and odds of endorsing any CUD symptoms. Among individuals endorsing at least one symptom, weekly flower use frequency (incident rate ratio [IRR]=1.06, <0.001) was positively associated with total symptom count, but weekly concentrate use frequency, cannabis quantity variables, and within-day frequency variables were not. Among individuals endorsing symptoms, a positive association was found between flower potency and total symptom count (IRR=1.01, =0.008). Current methods of assessing within-session cannabis quantity and within-day cannabis use frequency may lack clinical utility in examining college student CUD symptoms over and above weekly cannabis use frequency. Cannabis flower potency may prove useful in assessment of CUD symptom severity, but further research is warranted.
近年来，大学生的大麻使用量显著增加，18-25 岁的个体患大麻使用障碍（CUD）的风险增加。虽然每周大麻使用频率是衡量大麻消费的常用指标，但越来越多的科学研究对探索更精细的大麻使用指标感兴趣。目前，关于评估大麻使用量、日内频率和效力变量的临床实用性的研究有限。
我们使用了科罗拉多州 617 名本科生的横断面调查数据。利用两部分模型构建方法，检验了单次吸食大麻量和日内使用频率与出现任何 CUD 症状的几率和出现的 CUD 症状总数之间的关系。我们还检验了在报告了解最常使用产品中大麻素含量的样本子集（n=288）中，大麻花的效力是否与出现任何 CUD 症状的几率和出现的 CUD 症状总数相关。每周吸食大麻花的频率（比值比[OR]=1.27，<0.001）和每周吸食浓缩大麻素的频率（OR=1.10，=0.044）与出现任何 CUD 症状的几率增加呈正相关，但大麻使用量和日内频率变量则不然。此外，大麻花的效力与出现任何 CUD 症状的几率之间没有关联。在至少出现一种症状的个体中，每周吸食大麻花的频率（发生率比[IRR]=1.06，<0.001）与总症状数呈正相关，但每周吸食浓缩大麻素的频率、大麻使用量变量和日内频率变量则不然。在出现症状的个体中，发现大麻花的效力与总症状数呈正相关（IRR=1.01，=0.008）。
目前评估单次吸食大麻量和日内大麻使用频率的方法可能缺乏临床实用性，无法在检查大学生的 CUD 症状时超出每周大麻使用频率。大麻花的效力可能在评估 CUD 症状严重程度方面有用，但还需要进一步的研究。
