Hée P, Stampe Sørensen S, Bock J E, Fernandes A, Steentoft A
Eur J Obstet Gynecol Reprod Biol. 1987 Jul;25(3):195-201. doi: 10.1016/0028-2243(87)90099-2.
Thirteen healthy women in active labour received an intrathecal injection of morphine 1.0 mg. Eighty-five percent (11 patients) experienced acceptable or good pain relief. Analgesia set in 15-45 min after injection and reached a maximum after 15-120 min and lasted until delivery. Eighty-five percent (11 patients) of the patients developed mild side-effects i.e., pruritus, nausea and emesis. The intrathecal injection of morphine did not adversely affect the condition of the infant. Venous blood samples from the patients and umbilical cords for estimation of plasma morphine showed extremely low concentrations. No patients experienced any discomfort during the injection of morphine. These results indicate that morphine 1.0 mg administered intrathecally decreases labour pains to an acceptable level.
13名处于活跃期分娩的健康女性接受了鞘内注射1.0毫克吗啡。85%（11名患者）的患者疼痛缓解程度为可接受或良好。镇痛作用在注射后15 - 45分钟开始，15 - 120分钟后达到最大效果，并持续至分娩。85%（11名患者）的患者出现了轻度副作用，即瘙痒、恶心和呕吐。鞘内注射吗啡对婴儿状况没有不利影响。采集患者静脉血样本和脐带血样本以评估血浆吗啡浓度，结果显示浓度极低。在注射吗啡过程中，没有患者感到任何不适。这些结果表明，鞘内注射1.0毫克吗啡可将分娩疼痛降低到可接受水平。
