基于残疾调整生命年 (DALYs) 的 COVID-19 健康影响评估：系统评价方案。
Disability-adjusted life years (DALYs) based COVID-19 health impact assessment: A systematic review protocol.
机构信息
Faculty of Medicine and Health, School of Health, University of New England, Armidale, NSW, Australia.
School of Veterinary Medicine, Wollo University, Dessie, Amhara, Ethiopia.
出版信息
PLoS One. 2022 Sep 12;17(9):e0274468. doi: 10.1371/journal.pone.0274468. eCollection 2022.
BACKGROUND
COVID-19 is a highly contagious infectious disease that emerged in 2019. This disease is causing devastating health, socio-economic, and economic crises. More specifically COVID-19 is affecting both the quality and length of human life. The overall health impact of this disease is measured by the disability-adjusted life years which is the sum of the life years lost due to disability (the effect on the health quality) and the years life lost due to premature death (effect on the length of life). The purpose of this review is to summarise DALYs-based health impact publications and produce compiled and informative literature that can aid the health regulators to make evidence-based decisions on mitigating COVID-19.
METHODS
The review will be conducted using the PRISMA 2020 guidelines. The DALYs-based original observational and cross-sectional studies will be collected for assessing the health impact of COVID-19. Both the life quality and length impacts of COVID-19 will be reviewed. The life quality impact of COVID-19 will be measured using the life years lost due to disability (pre-recovery illness, pre-death illness, and post-acute consequences), and its impact on the length of life will be measured with years of life lost due to premature death (shortening of life expectancy). The combined health impact of COVID-19 on the quality and length of life will be measured in disability-adjusted life years.
DISCUSSION
The impacts of COVID-19 on the two health outcomes (quality and length of life) will indicate the level of COVID-19 health burden. The increase or decrease of COVID-19 health impact might be due to the sample size differences of different studies and the omission of years lost due to post-acute consequences in some studies. After having a summarized systematic review health decision-makers will apply an impact-based response to COVID-19.
TRAIL REGISTRATION
Systematic review registration: This protocol is pre-registered in PROSPERO with the registration number CRD42022324931.
背景
COVID-19 是一种于 2019 年出现的高传染性传染病。这种疾病正在造成毁灭性的健康、社会经济和经济危机。更具体地说，COVID-19 正在影响人类的生活质量和寿命。这种疾病的整体健康影响是通过残疾调整生命年来衡量的，残疾调整生命年是由于残疾而丧失的生命年（对健康质量的影响）和由于过早死亡而丧失的生命年（对寿命的影响）的总和。本综述的目的是总结基于残疾调整生命年的健康影响出版物，并提供综合和信息丰富的文献，以帮助卫生监管机构就减轻 COVID-19 做出基于证据的决策。
方法
本综述将使用 PRISMA 2020 指南进行。将收集基于残疾调整生命年的原始观察性和横断面研究，以评估 COVID-19 的健康影响。将审查 COVID-19 对生活质量和寿命的影响。COVID-19 对生活质量的影响将通过因残疾而丧失的生命年来衡量（发病前疾病、死亡前疾病和急性后后果），其对寿命的影响将通过因过早死亡而丧失的生命年来衡量（缩短预期寿命）。COVID-19 对生活质量和寿命的综合健康影响将以残疾调整生命年来衡量。
讨论
COVID-19 对这两个健康结果（生活质量和寿命）的影响将表明 COVID-19 健康负担的水平。COVID-19 健康影响的增加或减少可能是由于不同研究的样本量差异以及一些研究中忽略了急性后后果造成的生命损失。在进行了总结性系统综述后，卫生决策者将对 COVID-19 采取基于影响的应对措施。
试验注册
系统综述注册：本方案已在 PROSPERO 中预先注册，注册号为 CRD42022324931。
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