National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore.
Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Kirana Eye Hospital, Jakarta, Indonesia.
Ocul Immunol Inflamm. 2023 Sep;31(7):1342-1361. doi: 10.1080/09273948.2022.2117705. Epub 2022 Sep 12.
Ocular toxoplasmosis is the leading cause of posterior uveitis worldwide, affecting individuals acrossdifferent age groups. The key to reducing vision loss includes prompt diagnosis and treatment. However, despite the prevalence of ocular toxoplasmosis, there has been little consensus regarding its pathophysiology,clinical features, diagnosis, and especially management.
The data sources were literature reviews, including Pub Med and Medline databases. Search terms included toxoplasmosis, retinitis, vasculitis, vitritis, uveitis alone or in combination with, serum, aqueous, vitreous eye, ocular and review.
In this review paper, we have sought to provide an overview of the pathophysiology, epidemiology, and clinical features of the disease, both based on current literature and our own clinical experience. We have also discussed the use of serology, ocular fluid, and ophthalmic investigations that could further facilitate the diagnosis of ocular toxoplasmosis.Different management strategies have been reported worldwide, including newer approaches such as local therapy.
A better understanding of critical aspects of ocular toxoplasmosis will hopefully lead to reduced morbidity, including blindness associated with this condition.
眼弓形体病是全球后葡萄膜炎的主要原因，影响着不同年龄段的人群。减少视力丧失的关键在于及时诊断和治疗。然而，尽管眼弓形体病很常见，但对于其发病机制、临床特征、诊断，尤其是治疗方法，尚未达成共识。
资料来源为文献综述，包括 Pub Med 和 Medline 数据库。检索词包括弓形体病、视网膜炎、血管炎、玻璃体炎、单独或联合的葡萄膜炎、血清、房水、玻璃体眼、眼部和综述。
在这篇综述中，我们试图根据现有文献和我们自己的临床经验，对疾病的发病机制、流行病学和临床特征进行概述。我们还讨论了血清学、眼液和眼科检查的应用，这些方法可以进一步促进眼弓形体病的诊断。世界各地报道了不同的治疗策略，包括局部治疗等新方法。
更好地了解眼弓形体病的关键方面有望降低发病率，包括与该疾病相关的失明。
