单细胞中的社交网络。
Social networks in the single cell.
机构信息
School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE, USA.
出版信息
J Exp Bot. 2022 Sep 12;73(16):5355-5357. doi: 10.1093/jxb/erac284.
This article comments on: Chustecki JM, Etherington RD, Gibbs DJ, Johnston IG. 2022. Altered collective mitochondrial dynamics in the Arabidopsis msh1 mutant compromising organelle DNA maintenance. Journal of Experimental Botany 73, 5428-5439. Plant mitochondrial DNA (mtDNA) can become damaged in many ways. A major repair mechanism is homologous recombination, which requires an undamaged DNA template. Presumably, this template comes from a different mitochondrion in the same cell. Plant mitochondria undergo fission and fusion to form transient networks which could allow the exchange of genetic information. To test this hypothesis, Chustecki et al. (2022) used msh1 mutants with defective DNA repair, and showed that mitochondrial interactions increased, revealing a link between the physical and genetic behavior of mitochondria.
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Chustecki JM、Etherington RD、Gibbs DJ、Johnston IG。2022. Arabidopsis msh1 突变体中线粒体动力学的改变，损害了细胞器 DNA 的维持。实验植物学杂志 73，5428-5439。植物线粒体 DNA（mtDNA）可能会受到多种方式的损伤。一种主要的修复机制是同源重组，它需要一个未受损的 DNA 模板。据推测，这个模板来自同一个细胞中的另一个线粒体。植物线粒体经历分裂和融合，形成短暂的网络，这可能允许遗传信息的交换。为了验证这一假说，Chustecki 等人（2022 年）使用了具有缺陷 DNA 修复功能的 msh1 突变体，结果表明线粒体相互作用增加，揭示了线粒体物理和遗传行为之间的联系。
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