Autotaxin, PPARs, and FGF21: An Eye Opener for Progressive Liver Disease?
作者信息
Beuers Ulrich, Oude Elferink Ronald
机构信息
Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
出版信息
Cell Mol Gastroenterol Hepatol. 2022;14(5):1168-1169. doi: 10.1016/j.jcmgh.2022.08.009. Epub 2022 Sep 9.
Abstract
摘要
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本文引用的文献
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Mechanisms of pruritus in cholestasis: understanding and treating the itch.胆汁淤积性瘙痒的发病机制：理解和治疗瘙痒。
Nat Rev Gastroenterol Hepatol. 2023 Jan;20(1):26-36. doi: 10.1038/s41575-022-00687-7. Epub 2022 Oct 28.
2
Hepatocyte-Secreted Autotaxin Exacerbates Nonalcoholic Fatty Liver Disease Through Autocrine Inhibition of the PPARα/FGF21 Axis.肝细胞分泌的自分泌酶通过自分泌抑制 PPARα/FGF21 轴加剧非酒精性脂肪性肝病。
Cell Mol Gastroenterol Hepatol. 2022;14(5):1003-1023. doi: 10.1016/j.jcmgh.2022.07.012. Epub 2022 Aug 2.
3
Structure and function of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family: Tidying up diversity.外核苷酸焦磷酸酶/磷酸二酯酶（ENPP）家族的结构与功能：梳理多样性。
J Biol Chem. 2022 Feb;298(2):101526. doi: 10.1016/j.jbc.2021.101526. Epub 2021 Dec 24.
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Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis.自分泌酶活性可预测原发性硬化性胆管炎患者肝移植术后无复发生存率。
Sci Rep. 2019 Jun 11;9(1):8450. doi: 10.1038/s41598-019-44762-7.
5
Autotaxin is a valuable biomarker for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease.自分泌运动因子是预测非酒精性脂肪性肝病患者肝纤维化的一种有价值的生物标志物。
Hepatol Res. 2019 Oct;49(10):1136-1146. doi: 10.1111/hepr.13382. Epub 2019 Jul 4.
6
Serum Autotaxin is a Marker of the Severity of Liver Injury and Overall Survival in Patients with Cholestatic Liver Diseases.血清自分泌运动因子是胆汁淤积性肝病患者肝损伤严重程度和总生存期的一个标志物。
Sci Rep. 2016 Aug 10;6:30847. doi: 10.1038/srep30847.
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Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling.类固醇与自分泌运动因子的结合连接了胆汁盐和溶血磷脂酸信号传导。
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